345 Skin insulin resistance impairs skin barrier function in hyperglycemic and diabetic mouse models

Over a third of the world population is obese and thus at risk for Type 2 diabetes mellitus (T2DM). T2DM is associated with a plethora of skin diseases, such as impaired wound healing, dry and itchy skin, and Psoriasis. Yet, it remains unresolved whether diabetic skin complications are a direct consequence of impaired insulin/IGF-1 signaling (IIS) in the skin or occurs secondarily in response to metabolic alterations. The skin epidermis provides a structural and innate immune barrier that protects the organism from outside challenges and water loss.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Barrier Function Source Type: research