1015 Radiation therapy eradicates malignant T cells and is associated with improved survival in early-stage mycosis fungoides

We report here that low-dose radiation therapy (LDRT, 8 Gy) induced durable remissions of treated lesions. We hypothesized that treatment with LDRT may era dicate the malignant T cell clone within the treated site. To address this, we examined pre- and post-treatment biopsies from 20 lesional skin samples of 18 MF patients who received either 8 Gy LDRT (n=16) or topical steroids (n=4) with high-throughput T-cell receptor sequencing (HTS) of the TCRB ge ne to identify, quantify, and follow the malignant T cell clone.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: J.T. O'Malley, A. de Masson, E. Jalbert, A. Giobbie-Hurder, A. Gehad, E. Seger, N. LeBoeuf, C. Larocca, J.E. Teague, T. Kupper, P.M. Devlin, R.A. Clark Tags: Translational Studies Source Type: research