Copper-catalyzed ring-opening C(sp3)-N coupling of cycloketone oxime esters: access to 1 °, 2° and 3° alkyl amines.

Copper-catalyzed ring-opening C(sp3)-N coupling of cycloketone oxime esters: access to 1°, 2° and 3° alkyl amines.
Chem Commun (Camb). 2019 Apr 17;:
Authors: Tian L, Gao S, Wang R, Li Y, Tang C, Shi L, Fu J
Abstract
A novel copper-catalyzed C(sp3)-N coupling of cycloketone oxime esters with nitrogen nucleophiles has been realized. All of the N-aryl/alkylanilines, anilines and benzophenone imine could be employed in this protocol to produce a variety of 1°, 2° and 3° alkyl amines in one or two steps. These resultant cyano-containing alkyl amines were proven to be versatile synthetic building blocks in a variety of chemical transformations.
PMID: 30994128 [PubMed - as supplied by publisher]

Source: Chemical Communications - April 16, 2019 Category: Chemistry Authors: Tian L, Gao S, Wang R, Li Y, Tang C, Shi L, Fu J Tags: Chem Commun (Camb) Source Type: research