Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome

Accurate diagnosis and stratification of children with irritable bowel syndrome (IBS) remain challenging. Given the central role of recurrent abdominal pain in IBS, we evaluated the relationships of pediatric IBS and abdominal pain with intestinal microbes and fecal metabolites using a comprehensive clinical characterization and multiomics strategy. Using rigorous clinical phenotyping, we identified preadolescent children (aged 7 to 12 years) with Rome III IBS (n = 23) and healthy controls (n = 22) and characterized their fecal microbial communities using whole-genome shotgun metagenomics and global unbiased fecal metabolomic profiling.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Tags: Regular articles Source Type: research

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Publication date: Available online 24 May 2019Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Per M. HellströmAbstractIrritable bowel syndrome (IBS) is a chronic gastrointestinal symptom complex defined by abdominal pain and disturbed bowel habits over 3 months within a period of 6 months, in absence of any identifiable organic pathology. Over the years, speculations of the pathophysiology of IBS has moved from elusive central nervous symptoms impinging on psychosomatic disease, to objective signs of intestinal fermentation with abdominal bloating and intestinal dysmotility. The specific subgro...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
CONCLUSION: The study identified a number of inadequacies in the consumption of different nutrients, excessive carbohydrate intake, especially FODMAPs, identified by the respondents as responsible for a worsening of their conditions. By contrast, other food groups such as meat, eggs and dairy were consumed by the sample population in insufficient quantities.RESUMO CONTEXTO: A s índrome do intestino irritável é um distúrbio funcional crônico, no qual a dieta, principalmente o teor de fibra dietética e presença de carboidratos fermentativos (FODMAPs) podem influenciar nos princ...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
Experimental pain sensitivity was assessed in individuals with urologic chronic pelvic pain syndrome (UCPPS) as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. A series of computer-controlled pressure stimuli were delivered to the thumbnail bed, an asymptomatic site distant from the area of UCPPS pain that is considered to be indicative of overall body pain threshold. Stimuli were rated according to a standardized magnitude estimation protocol. Pain sensitivity in participants with UCPPS was compared with healthy controls and a mixed pain group composed of individuals wit...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Authors: Yan J, Miao ZW, Lu J, Ge F, Yu LH, Shang WB, Liu LN, Sun ZG Abstract Purpose: To comprehensively evaluate the efficacy and safety of acupuncture combined with Chinese herbal medicine (CHM) in treating irritable bowel syndrome with diarrhea (IBS-D). Methods: Relevant randomized controlled trials (RCTs) were systemically retrieved from electronic databases from inception to March 2018, including the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Biological Medical Database (CBM, SinoMed), China Science and Technology Journ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
This article presents the rationale for EAET, describes its principles and techniques, reviews its development and early testing as well as recent clinical trials, and critically analyzes the evidence base.Recent FindingsFour initial trials (between 2006 and 2011) demonstrated the efficacy of earlier versions of EAET. Four recent randomized, controlled trials of different EAET durations (1 to 8 sessions) and formats (individual or group) in patients with fibromyalgia, irritable bowel syndrome, pelvic pain, or medically unexplained symptoms support the earlier findings. EAET reliably reduces pain and interference, although ...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
AbstractIntroductionIrritable bowel syndrome (IBS), the most commonly diagnosed functional gastrointestinal (GI) disorder in developed countries, is characterized by chronic abdominal pain, and altered bowel habits.ObjectivesAccurate and timely diagnosis is challenging as it relies on symptoms and an evolving set of exclusion criteria to distinguish it from other related GI disorders reflecting a complex etiology that remains poorly understood. Herein, nontargeted metabolite profiling of repeat urine specimens collected from a cohort of IBS patients (n  =  42) was compared to healthy controls (n  = &th...
Source: Metabolomics - Category: Biology Source Type: research
Increased gut permeability might contribute to the pathogenesis of irritable bowel syndrome or functional abdominal pain (IBS or FAP). We investigated whether siblings and parents of children with IBS or FAP have increased gut permeability.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
By establishing a novel optical approach to determine neural activities with single ‐spike resolution via GCaMP6f, the current study characterizes the neural encoding from hundreds of colorectal afferents (~800) in the DRG, which are sparsely distributed and difficult to be recorded with conventional methods High‐threshold muscular afferents, that is, putative colorectal nocice ptors are clustered in the caudal region of the L6 DRG, which informs the spatially selective neuromodulation of colorectal nociceptors for better management of visceral pain. AbstractNeuromodulation as a non ‐drug alternative for managing vis...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
(IBS) is a functional gastrointestinal disorder characterized by chronic abdominal pain associated with a change in frequency and form of stool. IBS is common, with a population prevalence of around 10%, and causes a reduction in quality of life. Its pathophysiology remains incompletely understood, although abnormal communications within the brain –gut axis are considered to be important. IBS can be subclassified according to predominant bowel habit and/or pain. Treatments are directed towards improving symptoms and are multifaceted.
Source: Medicine - Category: Internal Medicine Authors: Tags: Motility and functional bowel disease Source Type: research
Centrally mediated abdominal pain and the associated narcotic bowel syndrome are functional bowel disorders that are challenging to manage and associated with significant medical harm, including unnecessary investigations, opioids and surgeries. They are distinguished from more common conditions, such as irritable bowel syndrome, by the near-continuous nature of the pain, irrespective of gastrointestinal physiological functioning. Their pathophysiology is obscure and incompletely understood, but they have features consistent with central sensitization.
Source: Medicine - Category: Internal Medicine Authors: Tags: Motility and functional bowel disease Source Type: research
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