New test could lead to personalized treatments for cystic fibrosis

The test combines high-speed video microscopy with a novel video analysis algorithm to measure the coordinated movement of cilia in the lungs.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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Source: Journal of Pediatric Health Care - Category: Pediatrics Authors: Tags: Department Pharmacology Continuing Education Posttest Source Type: research
Artem Sokolov1, Stephanie Ashenden2,3, Nil Sahin4,5, Richard Lewis2, Nurdan Erdem4, Elif Ozaltan4, Andreas Bender2, Frederick P. Roth5,6,7 and Murat Cokol1,4,5,8* 1Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, United States 2Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom 3Discovery Sciences, IMed Biotech Unit, AstraZeneca R&D, Cambridge, United Kingdom 4Faculty of Engineering and Natural Sciences, Sabanc─▒ University, Istanbul, Turkey 5Donnelly Centre, University of Toronto, Toronto, ON, Canada 6Department of Molecular Gene...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Cytomegalovirus (CMV) is a betaherpesvirus, the impacts of which are well known to clinicians providing post-transplant cystic fibrosis care. Lung transplant recipients have the highest risk of any solid-organ transplant for CMV reactivation and ganciclovir resistance [1, 2]. Furthermore, CMV reactivation increases the risk of chronic lung allograft dysfunction. However, even in general populations, CMV seropositivity is associated with adverse outcomes including cognitive impairment, frailty, heart disease and all-cause mortality [3–5]. How CMV may contribute to disease is not evident but many streams of evidence su...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Publication date: 23 April 2019Source: Cell Reports, Volume 27, Issue 4Author(s): Peter Jorth, Zarmina Ehsan, Amir Rezayat, Ellen Caldwell, Christopher Pope, John J. Brewington, Christopher H. Goss, Dan Benscoter, John P. Clancy, Pradeep K. SinghSummaryCulture and sequencing have produced divergent hypotheses about cystic fibrosis (CF) lung infections. Culturing suggests that CF lungs are uninfected before colonization by a limited group of CF pathogens. Sequencing suggests diverse communities of mostly oral bacteria inhabit lungs early on and diversity decreases as disease progresses. We studied the lung microbiota of CF ...
Source: Cell Reports - Category: Cytology Source Type: research
Condition:   Cystic Fibrosis, 10011762 Intervention:   Drug: Anakinra Sponsor:   Heidelberg University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Within the limitations of this study, CF patients were found to be at oral health risk due to the high prevalence of dental enamel defects. Oral health for CF children should be part of the multidisciplinary care. PMID: 31011138 [PubMed - as supplied by publisher]
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research
CONCLUSION: These new recommendations, close to French practices, help clinicians to find the right time for referral of patients to transplantation centers. This is crucial for the prognosis of lung transplantation. PMID: 31006579 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
In Cystic Fibrosis (CF), exercise ventilatory inefficiency and dynamic hyperinflation (DH) cause exercise limitation and induce poor exercise tolerance. High-resolution computed tomography (HRCT) of the lung c...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Research Source Type: research
Newborn bloodspot screening (NBS) for cystic fibrosis (CF) is a successful public health strategy with a considerable impact on the well-being of young people with CF [1]. Most infants with a positive NBS result for CF will have either a clear diagnosis of CF (true positive NBS result) or CF excluded (false positive NBS result), however a small but significant number will have an inconclusive diagnosis. This is a challenging situation for families and for healthcare professionals [2].
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research
Poshmaal Dhar1 and Julie McAuley2* 1Faculty of Health, School of Medicine, Deakin University, Geelong, VIC, Australia 2Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Melbourne, VIC, Australia The family of cell surface (cs-) mucins are constitutively expressed at the cell surface by nearly all epithelial cells, beneath the gel-mucin layer. All cs-mucin family members have structural features that enable them to act as a releasable decoy barrier to mucosal pathogens, by providing ligands for pathogen binding and the ability to shed the bound extracellular domain. Due ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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