Candida auris Spreads Through US Hospitals Candida auris Spreads Through US Hospitals

The tough new strain of fungus does not act'like your typical candida,'says an expert from the CDC.WebMD Health News
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news

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Publication date: Available online 15 April 2019Source: Carbohydrate PolymersAuthor(s): Alankar A. Vaidya, Ibrar Hussain, Marc Gaugler, Dawn A. SmithAbstractChitin is an abundant natural polymer and its deacetylated derivative chitosan has been a focus for the development of biobased, biocompatible and antimicrobial materials. In this work, a green and scalable route to grafting polycaprolactone (PCL) to chitosan using an enzyme catalysed reactive extrusion process is described. FTIR, 1H and 13C NMR spectroscopy and HSQC analysis confirm grafting of PCL to chitosan and show differences in the grafting pattern obtained usin...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Conclusion: This first nationwide epidemiologic study of pediatric candidemia confirmed a high incidence among neonates and a substantial burden of comorbidities. Moreover, an increasing proportion of fluconazole resistant nonalbicans species was observed. Our findings underline the importance of choosing correct treatment and continuous surveillance of pediatric candidemia.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Conclusion: This prospective multicenter study provides information on the current incidence and outcome of IFD in the real life setting. Practice variation between the centers may help to ultimately improve antifungal management in children at highest risk for IFDs. Introduction Available data on the incidence and outcome of invasive fungal diseases (IFD) in children treated for a hematological malignancy or undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are mostly based on single site, retrospective studies or on studies performed prior to the availability of newer compounds such as broad-sp...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, we developed a MCDA-LFB assay for rapid and effective detection of C. albicans. The LOD of the new assay for C. albicans detection from pure cultures was as low as 200 fg. In comparison to other molecular methods (PCR, LAMP) for detection of C. albicans, the MCDA-LFB method is more sensitive, time-saving, and does not require expensive equipment or diagnostic technology. When using the MCDA-LFB assay to detect infected clinical samples, the results were consistent with those of the gold-standard method. This suggests the possibility for further clinical application of our C. albicans-MCDA-LFB assay. Ethics ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, the three natural compounds 6-methoxymellein (3), angelicoin B (4) and ellagic acid as well as nine novel 3,4-dihydroisocoumarins (Figure 1) were analyzed regarding their cytotoxicity in cancer cells and inhibition of the endogenously expressed human ABC transporters P-gp, BCRP, and MRP1 and of the yeast transporter Pdr5. For further insights into the mechanism of action, Pdr5 ATPase and substrate transport assays were performed. These results were complemented with molecular docking studies that indicate that differences in the inhibitory power of the investigated 3,4-dihydroisocoumarins with respect to P-g...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 April 2019Source: LWTAuthor(s): Ayse Gunyakti, Meltem Asan-OzusaglamAbstractIn the current study, Lactobacillus gasseri MA-4 strain from human breast milk was evaluated for its probiotic potential and some technological properties. The strain was also evaluated for its virulency. The antimicrobial activity was tested against a wide range of clinical-human and food pathogenic bacteria, Candida species and various fish pathogens. High tolerance was observed by MA-4 strain for some essential parameters such as low pH, bile salts, artificial stomach and small intestine fluids conditions. T...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Conclusion: Bypass of tolerance by DAMPs might be a phenomenon as important as TI, since it could explain how chronic inflammation can be maintained in spite of an environment with multiple TLR2/TLR4-ligands. In RA monocytes, a PRDM8-dependent TI mechanism could be responsible for sustained chemokine/cytokines levels. Introduction Monocytes and macrophages play a central role in the pathophysiology of inflammation. For instance, in rheumatoid arthritis (RA), activated monocytes massively infiltrate synovial tissues and produce tumor necrosis factor-α (TNFα) (1–3). Accordingly, therapies aimed at b...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 April 2019Source: Carbohydrate PolymersAuthor(s): Carla Vilela, Helena Oliveira, Adelaide Almeida, Armando J.D. Silvestre, Carmen S.R. FreireAbstractThe design of functional materials capable of fighting fungal infections is of paramount importance given the intricate problem of multidrug-resistant pathogenic fungi. Herein, nanocomposites consisting of cross-linked poly([2–(methacryloyloxy)ethyl] trimethylammonium chloride) (PMETAC) and bacterial nanocellulose (BNC) were prepared, characterized and tested towards the polymorphic fungus Candida albicans. The BNC three-dimensional ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Source Type: research
We report a similar case but in a young adult who developed septic emboli due to DA that was caused by an infected peripherally inserted central catheter (PICC) line. Since the organism is highly susceptible to recurrent embolization, the PICC line was removed and the patient was treated successfully with an appropriate antibiotic regime.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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