Simple alkanoyl acylating agents for reversible RNA functionalization and control.

We describe the synthesis and RNA acylation activity of a series of minimalist azidoalkanoyl imidazole reagents, with the aim of functionalizing RNA at 2'-hydroxyl groups at stoichiometric to superstoichiometric levels. We find marked effects of small structural changes on their ability to acylate and be reductively removed, and identify reagents and methods that enable efficient RNA functionalization and control. PMID: 30977472 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30977472?dopt=Abstract

Source: Chemical Communications - April 11, 2019 Category: Chemistry Authors: Park HS, Kietrys AM, Kool ET Tags: Chem Commun (Camb) Source Type: research

More News: Chemistry