Prevalence and characteristics of likely-somatic variants in cancer susceptibility genes among individuals who had hereditary pan-cancer panel testing
Mosaicism is defined as the presence of two or more cell populations with unique genotypes in one individual. Low-level mosaicism is seen frequently in normal tissues, and particularly in those with higher turnover rates.[1] One such tissue is bone marrow, which produces the peripheral white blood cells that comprise a common source of genomic DNA used in next-generation sequencing (NGS) hereditary pan-cancer panel testing.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Thomas P. Slavin, Bradford Coffee, Ryan Bernhisel, Jennifer Logan, Hannah C. Cox, Guido Marcucci, Jeffrey Weitzel, Susan L. Neuhausen, Debora Mancini-DiNardo Tags: Original Article Source Type: research