Medical News Today: What to know about lip cancer

Lip cancer is a type of head and neck cancer that often starts with a lump on the lip that does not heal. Common risk factors for lip cancer include prolonged sun exposure, heavy alcohol intake, and tobacco use. Learn more about the symptoms, treatment, and prevention of lip cancer here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

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CONCLUSION: Bacteremia occurred mostly in active SLE patients and was frequently associated with severe flares and corticosteroid use. Recurrence and mortality were high. Immunosuppressors, comorbidities and disease-related damage were associated with bacteremia. PMID: 30988123 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Publication date: Available online 16 April 2019Source: Journal of Molecular StructureAuthor(s): A. Sunil Kumar, Jyothi Kudva, Manu Lahtinern, Anssi Peuronen, Rajitha Sadashiva, Damodara NaralAbstractThree quinazolin-4-ylamino derivatives containing phenylbenzenesulfonamides (7a-7c) were synthesized by reacting (E)-N'-(2-cyanophenyl)-N,N-dimethyl formamidine (6) with different 4-amino-N-(phenyl)benzenesulfonamides (4a-4c) and characterized by different techniques such as HRMS, IR, 1H NMR and 13C NMR spectroscopy. The structural properties were further examined by single crystal X-ray diffraction method. The X-ray data show...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB00651F, PaperAgata Campisi, Maria Assunta Chiacchio, Laura Legnani, Paola Bottino, Giuseppe Lanza, Daniela Iannazzo, Lucia Veltri, Salvatore V. Giofr è, Roberto ROMEO A series of 2,3,4-triaryl-substituted 1,2,4-oxadiazole-5-ones have been prepared as fixed-ring analogues of tamoxifen (TAM), a drug inhibitor of Estradiol Receptor (ER) used in breast cancer therapy, by an efficient synthetic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Biao Yu, Mingjun Zhang, Jiahuan Chen, Lingyu Wang, Xiaohuan Peng, Xinwei Zhang, He Wang, Anbei Wang, Dazhong Zhao, Daxin Pang, Hongsheng OuYang, Xiaochun TangAbstractAimsColorectal cancer syndrome has been one of the greatest concerns in the world. Although several epidemiological studies have shown that hepatic low lipoprotein lipase (LPL) mRNA expression may be associated with dyslipidemia and tumor progression, it is still not known whether the liver plays an essential role in hyperlipidemia of ApcMin/+ mice.Main methodsWe measured the expre...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Anand Thirupathi, Yan-Zhong ChangAbstractThe gradual energy dissipation of all organisms allows adapting to energy demands. Pathological situations of uncured diseases such as cancer, diabetes, and other obesity-related diseases are caused by an abrupt energy imbalance. As an energy sensor, AMP-activated kinase (AMPK) can regulate the cellular energy status. In case of increased energy demands or insufficient nutrient supply, cells digest their own interior, which is called autophagy. AMPK-mediated autophagy regulates various metabolic and phys...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 16 April 2019Source: Life SciencesAuthor(s): Sha-sha Wang, Ya-ling Tang, Xin Pang, Min Zheng, Ya-jie Tang, Xin-hua LiangAbstractOral epithelial barrier consists of closely controlled structure of the stratified squamous epithelium, which is the gateway to human bodies and encounters a huge burden of microbial, airborne and dietary antigens, as well as masticatory damage. Once this barrier is destroyed, it will trigger bone loss, tissue damage and microbial dysbiosis and lead to diseases, such as periodontitis, oral mucosal diseases and oral cancer. Recently, increasing evidences showed th...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 April 2019Source: Journal of Structural BiologyAuthor(s): Benjamin Zanghellini, Tilman A. Grünewald, Manfred Burghammer, Harald Rennhofer, Bernadette Liegl-Atzwanger, Andreas Leithner, Helga C. LichteneggerAbstractOsteosarcoma is the most common primary bone cancer type in humans. It is predominantly found in young individuals, with a second peak later in life. The tumour is formed by malignant osteoblasts and consists of collagenous, sometimes also mineralized, bone matrix. While the morphology of osteosarcoma has been well studied, there is virtually no information about the nan...
Source: Journal of Structural Biology - Category: Biology Source Type: research
Abstract Tumor hypoxia is a well-known microenvironmental factor that causes cancer progression and resistance to cancer treatment. Proline hydroxylases (PHDs), a small protein family, belong to an evolutionarily conserved superfamily of dioxygenases, considered the central regulator of the molecular hypoxia response. Prolyl-4-hydroxylase 2 (PHD2), one member of PHDs family, regulates the stability of the hypoxia-inducible factor-1 alpha (HIF-1α) in response to oxygen availability. During hypoxia, the inhibition of PHD2 permits the accumulation of HIF-1α, allowing the cellular adaptation to oxygen limi...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Abstract Fisetin (3,3',4',7-tetrahydroxyflavone) is a bioactive polyphenolic flavonoid found in many fruits and vegetables. It exhibits a variety of pharmacological activities including anticancer and anti-invasive effects. Epithelial to mesenchymal transition (EMT) allows the tumor cells to acquire increased migratory and invasive properties mediating their dissemination to faraway sites, thus favoring metastasis. With metastatic lung cancer claiming the majority of lung cancer-related deaths, agents targeting the pathways underlying metastasis are translationally promising. In the present study, we have explored...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Publication date: Available online 16 April 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Denise Wolrab, Robert Jirásko, Michaela Chocholoušková, Ondřej Peterka, Michal HolčapekAbstractThis review summarizes available mass spectrometry (MS) based approaches for the quantitative analysis of lipids in biological samples in the cancer research, which is termed here as oncolipidomics. The methodological part shows possible configurations of stand-alone MS or MS coupled to liquid-phase separation techniques for the characterization of various lipids with the special emphasis on methods conveni...
Source: TrAC Trends in Analytical Chemistry - Category: Chemistry Source Type: research
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