Isolation and identification of two new compounds from the twigs and leaves of Cephalotaxus fortunei

AbstractTwo new compounds, namely 5-hydroxy-7-methoxy-6-methylchromone (1), and sesquiterpene X (6), together with 21 known compounds were isolated from the twigs and leaves ofCephalotaxus fortunei Hook. f. The structures of1 –23 were elucidated on the basis of spectroscopic analysis (1D/2D NMR, HR-ESI –MS and IR) and comparison with literature. The absolute configuration of compound6 was determined by means of electronic circular dichroism calculation. The in vitro anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing lipopolysaccharide-induced nitric oxide production. Compounds1 and6 exhibited weak effects with percentage inhibitions of 24% and 35.60%, respectively. In addition, compounds4,9, and14 have the potential to be developed as therapeutic agents for inflammatory diseases because of their significant anti-inflammatory activities and high content inC. fortunei.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research