Recurrent Tonsillitis Tfh Cells Acquire a Killer Identity.
Recurrent Tonsillitis Tfh Cells Acquire a Killer Identity.
Trends Immunol. 2019 Apr 04;:
Authors: Baessler A, Hale JS
Abstract
Group A Streptococcus (GAS) infection causes recurrent tonsillitis (RT) in some individuals. A recent study (Dan et al. Sci. Transl. Med. 2019;11:eaau3776) demonstrates that RT is associated with an impaired antibody response against a key streptococcal virulence factor. This factor, SpeA, can induce abnormal T follicular helper (Tfh) cells that are able to kill B cells.
PMID: 30956068 [PubMed - as supplied by publisher]
Source: Trends in Immunology - Category: Allergy & Immunology Authors: Baessler A, Hale JS Tags: Trends Immunol Source Type: research