Food effect on meal administration time of pharmacokinetic profile of cilostazol, a BCS class II drug.

Food effect on meal administration time of pharmacokinetic profile of cilostazol, a BCS class II drug.
Xenobiotica. 2019 Apr 02;:1-18
Authors: Miyake M, Oka Y, Mukai T
Abstract
1. Cilostazol (CLZ) is categorized as a BCS class II drug. CLZ suspensions of jet-milled particles were orally administered to beagle dogs in fasted and fed states, for which food was given 0.5 h before the experiment. 2. The mean highest concentration of CLZ (Cmax) and the area under the serum concentration-time curve (AUCt) fed/fasted ratios were 2.90 and 2.85, respectively, indicating a large and variable food effect. Additionally, CLZ was administered to the same dogs at 2 and 4 h after food or 0.5 h before food. The serum concentrations of CLZ were similar when dosed 0.5 and 2 h after food; however, they were significantly lower when dosed 4 h after food but still greater compared with the fasted state. 3. Furthermore, the ratio of fed/fasted in AUCt was better correlated than that in Cmax. Additionally, the serum concentrations were similar to the fasted states when CLZ was dosed 0.5 h before food. 4. Therefore, the results of this study showed that the serum concentration-time profile of CLZ was significantly affected by the timing of food administration, and that a good correlation was observed between food administration time and the Cmax and AUCt fed/fasted ratios.
PMID: 30938549 [PubMed - as supplied by publisher]

Source: Xenobiotica - April 1, 2019 Category: Research Authors: Miyake M, Oka Y, Mukai T Tags: Xenobiotica Source Type: research