Endobronchial Obstruction by a Solitary Extramedullary Plasmacytoma With Light-chain Amyloidosis

No abstract available
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Online Articles: Letters to the Editor Source Type: research

Related Links:

Conclusions: Adult periocular colloid milium is an unusual presentation of a rare cutaneous deposition disease. The occurrence of conjunctival colloid milium is rare, and we report this case to increase knowledge and management regarding this rare disease and to differentiate it from other diseases such as amyloidosis, lipoid proteinosis, plasmacytoma, and conjunctival lymphoma, which carry a graver prognosis, and have a similar clinical appearance and can be distinguished only on the basis of histopathological characteristics.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
INTRODUCTION: Despite advances in therapy, patients with relapsed AL amyloidosis die of resistant disease. New therapies are needed. siRNA directed at the constant regions of Ig light chains (LC) reduces LC mRNA and protein from patient cells, from human myeloma and AL cell lines, and in a flank plasmacytoma model with in vivo electroporation (Blood 2014;123:3440; Gene Ther 2016;23:727). To deliver siRNA in vivo, we first tested a series of biodegradable lipidoid nanoparticles (LPN) generated through Michael addition of aliphatic acrylates containing disulfide bonds responsive to intracellular glutathione that enhance siRN...
Source: Blood - Category: Hematology Authors: Tags: 652. Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy: Poster II Source Type: research
Conclusion:This is the first report on the management of MM patients in UAE. With a median follow-up of 216 days (range 3 to 839 days) the response rate to induction therapy was 72% (CR+ VGPR). We are unable to report progression free survival due to short follow-up. This response rate of 72% (VGPR or better) is less than the reported in the literature. This may partly be due to lack of patient data regarding induction therapy elsewhere, the use of double over triplet regimens and the absence of autoSCT facilities. Outcome measurement is a difficult task due to tendency of local citizens to travel outside UAE for treatment...
Source: Blood - Category: Hematology Authors: Tags: 653. Myeloma: Therapy, excluding Transplantation Source Type: research
Plasma cell neoplasms (PCNs) are characterized by the uncontrolled clonal expansion of genetically altered plasma cells. These diseases include the precursor lesion monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, plasma cell myeloma (or multiple myeloma), plasmacytoma, monoclonal immunoglobulin deposition diseases (amyloidosis), and PCNs associated with paraneoplastic syndromes. While karyotype and fluorescence in situ hybridization (FISH) analyses have been instrumental in determining prognosis and guiding therapy, the clinical significance of new and emerging molecular markers raise the nee...
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Tags: Review Article Source Type: research
The Breast Journal, EarlyView.
Source: The Breast Journal - Category: Cancer & Oncology Authors: Source Type: research
Abstract: Pulmonary disorders are reported as rare extraintestinal manifestations of inflammatory bowel diseases. However, according to current literature, they are clinically underrecognized and likely underdiagnosed. While both parenchymal and airway lesions have been described, inflammatory bowel disease seems to preferentially affect the tracheobronchial tree, where it induces bronchiectasis, tracheobronchitis, and bronchitis. Respiratory involvement typically appears during a long-lasting disease, although symptoms of airway involvement may appear following surgery. Pathology features of tracheobronchitis have been do...
Source: Pathology Case Reviews - Category: Pathology Tags: Case Reports Source Type: research
Authors: Kumar SK, Callander NS, Alsina M, Atanackovic D, Biermann JS, Chandler JC, Costello C, Faiman M, Fung HC, Gasparetto C, Godby K, Hofmeister C, Holmberg L, Holstein S, Huff CA, Kassim A, Liedtke M, Martin T, Omel J, Raje N, Reu FJ, Singhal S, Somlo G, Stockerl-Goldstein K, Treon SP, Weber D, Yahalom J, Shead DA, Kumar R Abstract Multiple myeloma (MM) is caused by the neoplastic proliferation of plasma cells. These neoplastic plasma cells proliferate and produce monoclonal immunoglobulin in the bone marrow causing skeletal damage, a hallmark of multiple myeloma. Other MM-related complications include hyperca...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
ConclusionOur analysis suggests that concurrent AL and soft tissue plasmacytoma were associated with shorter PFS and OS, respectively. Heterogeneity in clinical outcome of SR MM merits better tools for prognostication, such as gene expression profiling and minimal residual disease assessment to identify high‐risk patients.
Source: European Journal of Haematology - Category: Hematology Authors: Tags: Original Article Source Type: research
Abstract Some dermatologic entities are strongly associated with the presence of a monoclonal gammopathy. They should be referred to as monoclonal gammopathy of cutaneous significance (MGCS). A short review of the main entities that fit into the spectrum of MGCS is provided. Amyloidosis, macroglobulinoderma and follicular hyperkeratotic spicules result from extravascular immunoglobulin or immunoglobulin‐related protein deposition. Skin findings include papules and plaques, follicular spicules, purpura, haemorrhagic bullae, macroglossia and nail changes. The skin findings in cryoglobulinemia (CG) result from vascular immu...
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Review Article Source Type: research
A 52-year-old woman presented with a large partially yellow and erythematous tumor on her right temple. She reported that it had grown over the last 4 years. Regional lymph nodes were impalpable. A punch biopsy showed eosinophilic material in the dermis and subcutis. Immunohistochemistry showed positive staining for kappa and lambda light chains. Electron microscopy showed the typical amyloid fibrils (7–10 nm in diameter). There was no evidence of systemic amyloidosis, paraproteinemia or underlying plasmacytoma. The tumor was completely removed via curettage. At follow-up, the patient presented in good health with no...
Source: Case Reports in Dermatology - Category: Dermatology Source Type: research
More News: Amyloidosis | Plasmacytoma | Respiratory Medicine