Fibroblast growth factors in skeletal development.

Fibroblast growth factors in skeletal development.
Curr Top Dev Biol. 2019;133:195-234
Authors: Ornitz DM, Marie PJ
Abstract
Fibroblast growth factors (FGFs) and their receptors (FGFRs) are expressed throughout all stages of skeletal development. In the limb bud and in cranial mesenchyme, FGF signaling is important for formation of mesenchymal condensations that give rise to bone. Once skeletal elements are initiated and patterned, FGFs regulate both endochondral and intramembranous ossification programs. In this chapter, we review functions of the FGF signaling pathway during these critical stages of skeletogenesis, and explore skeletal malformations in humans that are caused by mutations in FGF signaling molecules.
PMID: 30902253 [PubMed - in process]

Source: Current Topics in Developmental Biology - March 25, 2019 Category: Biology Authors: Ornitz DM, Marie PJ Tags: Curr Top Dev Biol Source Type: research