Continuous versus bolus infusion of hypertonic saline in the treatment of symptomatic hyponatremia due to SIAD.

CONCLUSION: 3% saline bolus produces faster initial elevation of pNa than continuous infusion of saline, with quicker restoration of GCS, and without osmotic demyelination. Frequent electrolyte monitoring, and judicious intervention with dDAVP is required to prevent overcorrection with bolus therapy.
PMID: 30882872 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - March 17, 2019 Category: Endocrinology Authors: Garrahy A, Dineen R, Hannon AM, Cuesta M, Tormey W, Sherlock M, Thompson CJ Tags: J Clin Endocrinol Metab Source Type: research