Standard Brachytherapy Underused in Cervical Cancer
(MedPage Today) -- Black race, higher-stage disease tied to lower likelihood of receiving boost
Conclusions: Unlike past results, gemcitabine and cisplatin appear to be tolerable, efficient and feasible when combined with conformal radiotherapy.
Tatsuya Ohno Recent widespread use of three-dimensional image-guided brachytherapy (3D-IGBT) has improved radiotherapy outcomes of cervical cancer dramatically. In 2018, the International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer was revised. However, the influence of the revisions on the stage distribution and outcomes of cervical cancers treated with 3D-IGBT remains unclear. Here, we retrospectively analyzed 221 patients with cervical squamous cell carcinoma treated with definitive radiotherapy using 3D-IGBT (median follow-up, 60 months). The stage distribution and outcomes ...
Shueng The aim was to compare the clinical outcomes and prognostic factors of cervical cancer between elderly and younger women, and to explore which treatment strategy is more appropriate for elderly patients. We retrospectively reviewed patients with cervical cancer receiving definitive radiotherapy (RT) between 2007 and 2016, and divided them into two age groups: age < 70 vs. age ≥ 70. The clinical outcomes were compared between the two age groups. The median follow-up was 32.2 months. A total of 123 patients were eligible, 83 patients in group 1 (age < 70), and 40 patients in group 2 (age &...
(Medical College of Georgia at Augusta University) The sugar coating on cancer cells helps them thrive, and a new study indicates patients with cervical cancer who make antibodies to those sugars appear to do better when they also receive internal radiation therapy.
The American Society for Radiation Oncology (ASTRO) has released its first...Read more on AuntMinnie.comRelated Reading: FDG-PET/CT points to cervical cancer patient outcomes Patient navigation boosts women's screening compliance ASTRO: Cervical cancer deaths rise as women's centers close 3D printing customizes brachytherapy for cervical cancer Medicaid expansion boosted cancer screening rates
(American Society for Radiation Oncology) A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations for radiation therapy to treat patients with nonmetastatic cervical cancer. The guideline--ASTRO's first for cervical cancer--outlines indications and best practices for external beam radiation therapy and brachytherapy in the postoperative and definitive settings. Recommendations also address other treatments including chemotherapy and surgery when used in combination with radiation. The guideline is published online in Practical Radiation Oncology.
The purpose of this study is to explore knowledge-based organ-at-risk dose estimation for intracavitary brachytherapy planning for cervical cancer. Using established external-beam knowledge-based dose-volume histogram (DVH) estimation methods, we sought to predict bladder, rectum, and sigmoid D2cc for tandem and ovoid treatments.
This study aimed to evaluate the rectal volume and dose-volume histogram (DVH) relationship in high-dose-rate (HDR) brachytherapy in locally advanced cervical cancer. Material and methods: Planning computed tomography of 65 patients who underwent HDR brachytherapy boost as a component of definitive radiotherapy from March 2016 to February 2018 were reviewed. OARs and target volume were re-delineated by a single physician to decrease interobserver variation. Two sets of plan were generated; in the first set, the dose was prescribed to point A with Manchester system loading pattern, while in the second set, the dose was ...
Conclusions: There is a need to ensure consistency in vaginal points reporting. The impact of the dosimetric inter- and intra-observer variability should also be considered when dealing with dose tolerances and limits due to the potential dose gradient. PMID: 32395138 [PubMed]
Conclusions: Extended treatment planning time for brachytherapy due to the changes in topography of small pelvis can lead to different dose in high-risk organs than previously planned. It seems that the most significant changes are related to rectum. PMID: 32395135 [PubMed]