Trauma exposure and mental health problems among adults in Central Vietnam: a randomized cross-sectional survey - Do TTH, Correa-Velez I, Dunne MP.

Background: There is relatively little evidence about the psychological and social impacts of trauma exposure in the general population in East Asian countries. Vietnam has a long history of war and poverty, is prone to natural disasters and has hig...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

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Research ArticlesM. Waller, F. J. Charlson, R. E. E. Ireland, H. A. Whiteford, A. J. Dobson,Epidemiology and Psychiatric Sciences,Volume 25 Issue 04, pp 393-402Abstract
Source: Epidemiology and Psychiatric Sciences - Category: Epidemiology Source Type: research
In conclusion, induced membrane (Masquelet) technique is a safe, simple and reliable method for treating segmental bone defect. The major complications of this technique include infection and graft resorption. PMID: 30879442 [PubMed - in process]
Source: Acta Orthopaedica Belgica - Category: Orthopaedics Tags: Acta Orthop Belg Source Type: research
Tourists cool off from high temperatures on the beach at the archaeological site of Tulum, in the southeastern Yucatan peninsula, an area of Mexico highly vulnerable to climate change. Powerful hurricanes, storms, drought, heat waves and rising sea levels are climate change effects that impact the mental health of the country's population. Credit: Emilio Godoy/IPSBy Emilio GodoyMEXICO CITY, Mar 19 2019 (IPS) Minerva Montes lost her home on Holbox Island in 2005 when Hurricane Wilma hit the Yucatan Peninsula in southeastern Mexico. Rebuilding her home was quicker and easier than overcoming the psychological aftermath of the...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Climate Change Development & Aid Editors' Choice Environment Featured Headlines Health Latin America & the Caribbean Population Regional Categories Source Type: news
BACKGROUND: Posttraumatic stress disorder (PTSD) after childhood abuse (CA) is often related to severe co-occurring psychopathology, such as symptoms of borderline personality disorder (BPD). The ICD-11 has included Complex PTSD as a new diagnosis, which i...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Individuals with post-traumatic stress disorder avoid trauma-related stimuli and exhibit blunted hypothalamic–pituitary–adrenal axis response at the time of trauma. Our laboratory uses predator odor (i.e. bobcat urine) stress to divide adult Wistar rats into groups that exhibit high (avoiders) or low (nonavoiders) avoidance of a predator odor-paired context, modeling the fact that not all humans exposed to traumatic events develop psychiatric conditions. Male avoiders exhibit lower body weight gain after stress, as well as extinction-resistant avoidance that persists after a second stress exposure. These animal...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: REVIEW ARTICLES Source Type: research
We present the hypothesis that altered stress reactivity as a result of brain injury impacts the amygdala and defense systems to be vulnerable to increased fear and PTSD development from traumatic stress. Identifying biological mechanisms that underlie this vulnerability, such as dysregulated HPA axis function, may lead to better targeted treatments and preventive measures to support psychological health after TBI.
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: REVIEW ARTICLES Source Type: research
In this review, we advocate a dimensional approach on the basis of candidate endophenotypes to the development of animal models of post-traumatic stress disorder (PTSD) capable of including genetic liability factors, variations in symptoms profile and underlying neurobiological mechanisms, and specific comorbidities. Results from the clinical literature pointed to two candidate endophenotypes of PTSD: low sensory gating and high waiting impulsivity. Findings of comparative studies in mice of two inbred strains characterized by different expressions of the two candidate endophenotypes showed different strain-specific neural...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: REVIEW ARTICLES Source Type: research
Understanding the neurobiological basis of post-traumatic stress disorder (PTSD) is fundamental to accurately diagnose this neuropathology and offer appropriate treatment options to patients. The lack of pharmacological effects, too often observed with the most currently used drugs, the selective serotonin reuptake inhibitors (SSRIs), makes even more urgent the discovery of new pharmacological approaches. Reliable animal models of PTSD are difficult to establish because of the present limited understanding of the PTSD heterogeneity and of the influence of various environmental factors that trigger the disorder in humans. W...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: REVIEW ARTICLES Source Type: research
Serotonin, one of the first neurotransmitters to be identified, is an evolutionarily old molecule that is highly conserved across the animal kingdom, and widely used throughout the brain. Despite this, ascribing a specific set of functions to brain serotonin and its receptors has been difficult and controversial. The 2A subtype of serotonin receptors (5-HT2A receptor) is the major excitatory serotonin receptor in the brain and has been linked to the effects of drugs that produce profound sensory and cognitive changes. Numerous studies have shown that this receptor is upregulated by a broad variety of stressors, and have re...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: REVIEW ARTICLES Source Type: research
In conclusion, edaravone ameliorated oxidative stress and cognitive impairment associated with a PTSD model, probably by supporting antioxidant mechanism in the hippocampus.
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: RESEARCH REPORTS Source Type: research
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