IL-33trap is a novel IL-33 neutralizing biologic that inhibits allergic airway inflammation

IL-33 is an important therapeutic target in allergic diseases. Here we describe the generation and biological activity of a novel IL-33 antagonist, IL-33trap, which shows anti-inflammatory activities in a preclinical mouse model for acute allergic airway inflammation.

Source: Journal of Allergy and Clinical Immunology - March 11, 2019 Category: Allergy & Immunology Authors: Aurora Holgado, Harald Braun, Elien Van Nuffel, Sammy Detry, Martijn J. Schuijs, Kim Deswarte, Karl Vergote, Mira Haegman, Griet Baudelet, Jurgen Haustraete, Hamida Hammad, Bart N. Lambrecht, Savvas N. Savvides, Inna S. Afonina, Rudi Beyaert Source Type: research