WHO Announces New Global Plan to Fight Flu

(MedPage Today) -- Emphasizes preparedness for the next pandemic for every country
Source: MedPage Today Public Health - Category: American Health Source Type: news

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Conclusionsthis study highlights the importance of surveillance of XDR strains, even outside densely populated cosmopolitan regions, to reveal the epidemiology of pandemic lineages, stressing their threat to public health.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Comparative studies of mucosal humoral and cellular immune responses to 2009 pandemic H1N1 influenza virus in mice. Acta Virol. 2019;63(2):203-210 Authors: Zhang YY, An J, Wang K, Han B, Liu YF, Jia HL, Li YS, Lei L, Jia N, Lv J Abstract The nasal-associated lymphoid tissues (NALTs), embedded in the submucosa of murine upper respiratory tract, represents an important site of induction for local mucosal immune responses to airborne pathogens and intranasal vaccines. Here, we systematically investigated the mucosal humoral and cellular immune responses of NALTs in mice infected with A/Beijing/501/2...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
Abstract The 1918 "Spanish" pandemic is the earliest known influenza H1N1 virus. Since then H1N1 viruses circulated between humans and animals continuously. With the increased amount of samples of H1N1 viruses and technology development, researchers have been studying how the viruses evolved. Here, we analyzed HA and NA genes of H1N1 viruses from three aspects: host distribution, geographical distribution and phylogenetic analysis. The data showed hosts were predominantly human, swine and poultry, and other hosts were mainly cat, ferret, wild bear, canine, cheetah and seal. In terms of geographical distr...
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
In this study, we reconstruct the dynamics of dissemination of early divergent non-pandemic subtype B lineages (designated BCAR) in Hispaniola. To this end, we analyzed 127 HIV-1 subtype B pol sequences collected in Haiti between 2009 and 2014, combined with BCAR pol sequences from Haiti (n = 12) and the Dominican Republic (n = 123) previously described. Phylogenetic analyses supported that BCAR strains account for most (>70%) of HIV-1 subtype B infections in Haiti. The BCAR strains from Haiti and the Dominican Republic were highly intermixed among each other, although the null hypothesis of completely random mixing was...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Despite the availability of yearly vaccinations, influenza continues to cause seasonal and pandemic rises in illness and death. An error prone replication mechanism results in antigenic drift and viral escape from immune pressure, and recombination results in antigenic shift that can rapidly move through populations that lack immunity to newly emergent strains. The development of a “universal” vaccine is a high priority and many strategies have been proposed, but our current understanding of influenza immunity is incomplete making the development of better influenza vaccines challenging. Influenza immunity has ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study is nested within a randomised controlled trial investigating LAIV–microbiome interactions (NCT02972957).FindingsBetween Feb 8, 2017, and April 12, 2017, 118 children were enrolled and received one dose of the Cal09 LAIV from 2016–17. Between Jan 15, 2018, and March 28, 2018, a separate cohort of 135 children were enrolled and received one dose of the NY15 LAIV from 2017–18, of whom 126 children completed the study. Cal09 showed impaired pH1N1 nasopharyngeal shedding (16 of 118 children [14%, 95% CI 8·0–21·1] with shedding at day 2 after administration of LAIV) compared with ...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Authors: Adalja A, Inglesby T PMID: 31216912 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Preventing new human immunodeficiency virus (HIV) infections is essential to halting the global pandemic. HIV prevention strategies include integrating both nonpharmacologic (eg, safe sexual counseling, circumcision) and pharmacologic approaches. Several pharmacologic HIV prevention strategies are increasingly used globally and include postexposure prophylaxis, preexposure prophylaxis, and treatment as prevention. These prevention modalities have enormous clinical and public health appeal, as they effectively reduce HIV acquisition in individuals and also may lower HIV incidence in communities when integrated and implement...
Source: Infectious Diseases Clinics of North America - Category: Infectious Diseases Authors: Source Type: research
Authors: Yimer EM, Tuem KB, Karim A, Ur-Rehman N, Anwar F Abstract The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic,...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
AbstractObjective and designType 2 diabetes is a pandemic disease characterized by hyperglycemia, ineffective insulin use, and insulin resistance and affecting 1 in 11 people worldwide. Inflammation-related insulin resistance is thought to play an important role in the etiology of the disease. TLR4 is the central receptor of the natural immune system and has an important role as a trigger of the inflammatory response. The IRAK1 and TIRAP are members of the TLR4 pathway and involved in the TLR4-mediated inflammatory response. Genetic variants in the TLR4 gene or in the IRAK1 and TIRAP genes may have an important role in the...
Source: Inflammation Research - Category: Research Source Type: research
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