Impact of USP8 gene mutations on protein deregulation in Cushing's disease.

CONCLUSIONS: We could demonstrate that USP8 mutations are associated with deregulation of p27/kip1, HSP90, and phosphorylated CREB. These findings suggest that these proteins are direct or indirect clients of USP8 and could therefore be potential targets for therapeutic approaches in patients with CD.
PMID: 30844069 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - March 6, 2019 Category: Endocrinology Authors: Weigand I, Knobloch L, Flitsch J, Saeger W, Monoranu CM, Höfner K, Herterich S, Rotermund R, Ronchi CL, Buchfelder M, Glatzel M, Hagel C, Fassnacht M, Deutschbein T, Sbiera S Tags: J Clin Endocrinol Metab Source Type: research