Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance

Granulomatosis with polyangiitis (GPA) is an autoimmune vasculitis associated with anti-neutrophil-cytoplasmic antibodies (ANCA) against proteinase 3 leading to kidney damage. Neutrophils from those patients have increased expression of membrane proteinase 3 during apoptosis. Here we examined whether neutrophils from patients with GPA have dysregulated protein expressions associated with apoptosis. A global proteomic analysis was performed comparing neutrophils from patients with GPA, with healthy individuals under basal conditions and during apoptosis.

Source: Kidney International - March 3, 2019 Category: Urology & Nephrology Authors: Judith Everts-Graber, Katherine R. Martin, Nathalie Thieblemont, Julie Mocek, Arnaud Roccabianca, Philippe Chafey, Morgane le Gall, Pascale Tacnet-Delorme, Chris Reutelingsperger, Jean-Marc Naccache, Bernard Bonnotte, Alexandre Karras, Xavier Pu échal, L Tags: Basic Research Source Type: research