Difengpienols A and B, two new sesqui-neolignans with anti-inflammatory activity from the bark of Illicium difengpi

Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Zheng-Hong Pan, Ling Cheng, De-Sheng Ning, Li-Yan Peng, Yu-Xia Fu, Lian-Chun LiAbstractAs part of our ongoing search for novel and bioactive natural products in Karst plants, two new sesqui-neolignans, difengpienol A (1) and difengpienol B (2), together with two known analogues (3 and 4), were isolated from the stem bark of Illicium difengpi. Their structures were elucidated by analysis of spectroscopic data. Difengpienol A (1) possessed a unique 1, 4-dibenzodioxocine moiety. All isolates were evaluated for inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages cells. Compounds 1 and 2 showed moderate inhibitory effects on NO production with IC50 values of 16.9 and 23.8 μM. A biosynthetic pathway was also proposed for 1 and 2.Graphical abstract

Source: Phytochemistry Letters - March 1, 2019 Category: Chemistry Source Type: research