Clonotypic diversity of the T-cell receptor corroborates the immature precursor origin of cutaneous T-cell lymphoma.

CONCLUSIONS: These findings can be explained by a model where malignant transformation takes place during early T-cell development giving rise to circulating pre-malignant clones which home to the skin producing clinically apparent lesions of cutaneous lymphoma. Therapeutic strategies in T-cell lymphoma should therefore target those early lymphoma precursor cells.
PMID: 30808775 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - February 26, 2019 Category: Cancer & Oncology Authors: Hamrouni A, Fogh H, Zak ZL, Odum N, Gniadecki R Tags: Clin Cancer Res Source Type: research