Potential for genetic therapies in autism and developmental delay

Date: Tuesday, 03 05, 2019; Speaker: Stephan Sanders, PhD, UCSF; Building: 35; 640
Source: NIH Calendar of Events - Category: American Health Source Type: events

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ConclusionsResearch on ER in young children with ASD is in its infancy with many of the studies reviewed being preliminary in nature. Furthermore, the majority of studies include participants that encompass a broad age range, making it difficult to distinguish the nature and occurrence of ER in toddlers and preschoolers with ASD from ER in older children and adolescence with ASD. Nonetheless, the review provides some insight into the nature of ER in young children with ASD and highlights important directions for future research.
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
ConclusionsMulti-method assessment is vital in understanding sleep problems in children with ASD. Broad estimates of quantity of sleep do not necessarily describe the difficulties experienced. Using questionnaires in addition to objective measurement may be a means to understand sleep problems in children with ASD and to an improved understanding of their impact.
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
In this study, we present the Spanish validation of the Reading the Mind in the Voice (RMV-SV) task, (Rutherford et al., 2002), an instrument for the recognition of mental states and complex emotions through prosody.MethodA group of adults diagnosed with autism spectrum disorders (ASD, n = 45) were compared to a control group from the general population (n = 51) in several emotion-recognition tasks.ResultsThe ASD group performed worse than controls overall on complex emotion and mental state recognition from voices (ŋ2 = .322; p 
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
Publication date: 21 August 2019Source: Neuron, Volume 103, Issue 4Author(s): Leonard K. KaczmarekMutations in voltage-dependent sodium channels cause severe autism/intellectual disability. In this issue of Neuron, Spratt et al. (2019) show that lowering expression of Nav1.2 channels attenuates backpropagation of action potentials into dendrites of cortical neurons, preventing spike-timing-dependent synaptic plasticity.
Source: Neuron - Category: Neuroscience Source Type: research
– Somryst app by Pear Therapeutics Digital therapeutics have potential but commercial success unproven (Vantage): “Developing drugs to treat disorders of the central nervous system is famously fraught with difficulty. Several companies, including Pear Therapeutics and Dthera, are taking a wildly different approach: digital therapeutics. These are pieces of software designed to treat disease that are regulated, prescribed and even paid for as if they were drugs … Pear is so far the only company to have brought a digital therapeutic to market – but it is by no means the only company in this space. Ak...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Akili Interactive AKL-T01 Click Therapeutics cognitive dysfunction digital therapeutics Dthera Pear Therapeutics Somryst Source Type: blogs
The definition of autism has changed so much that it prevents a better understanding of how the autistic brain works, the lead researcher of a new review says.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news
Do you enjoy watching YouTube videos on psychology and mental health topics?  But are you tired of wading through all the mindless fluff, meaningless new-age jargon, and overly pedantic lectures?  There is a better option out there – The Psych Show, created by Dr. Ali Mattu.   It might seem frivolous, but YouTube videos aren’t going anywhere. They have become one of the most common ways we access information, and this is especially true for young people. Join us as Dr. Mattu tells us how a PhD psychologist became one of the first YouTubers, how he decides what type of content to feature ea...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Podcast Psychiatry Psychology Self-Help The Psych Central Show Source Type: blogs
Somerville biotech Finch Therapeutics Group Inc. could be one of the first local startups hoping to use natural bacteria to fight chronic diseases to bring a product to the market.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Translational Psychiatry, Published online: 22 August 2019; doi:10.1038/s41398-019-0545-zBehavioral predictors of autism recurrence are genetically independent and influence social reciprocity: evidence that polygenic ASD risk is mediated by separable elements of developmental liability
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
Conclusions: Our findings suggest that impairments in brain regions involved in processing social contingencies embedded in dynamic cartoons are present from an early age in autism spectrum disorder. To the best of our knowledge, this is the first study to investigate neural processing of social interactions of children with autism spectrum disorder using dynamic semi-naturalistic stimuli.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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