GSE78269 Altered cell signaling in the absence of Dynamin function: a transcriptomic approach from yeast to humans (human)

Contributors : Maria S Dominguez-Sanchez ; Tatiana Alfonso-Perez ; Macarena Morillo-Huesca ; Monica Perez-Alegre ; E Andujar ; V Bachetti ; Mario Garcia-Dominguez ; C ReyesSeries Type : Expression profiling by arrayOrganism : Homo sapiensDynamins are large multidomain GTPases involved in membrane scission. We have investigated the transcriptional consequences of deleting DNM2 by siRNA in HeLa cells. Interestingly, DNM2 depletion causes strong transcriptional defects.Data suggest that DNM2 playes an essential regulatory role connecting several membrane-related processes including endocytosis, lipid homeostasis and different signal transduction pathways.

Source: GEO: Gene Expression Omnibus - February 24, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research