A primer on ageing studies in mice: Considerations, opportunities and limitations

Publication date: Available online 23 February 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Paul K. PotterOne of the major challenges currently facing health care providers is an ageing population that is spending more time in ill-health. Many ageing individuals have multiple and complex needs which affect the ability to treat them effectively, which also has a significant impact on their own independence and quality of life. There are many aspects of testing interventions to improve health in old age in pre-clinical models; from breeding strategies to measurements of outcomes. Here we provide a brief overview of the major considerations to take into account in such studies and the limitations or challenges we face in these studies.
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research