B cell-intrinsic requirement for STK4 in humoral immunity in mice and humans

Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are intrinsic to the B cells.

Source: Journal of Allergy and Clinical Immunology - February 20, 2019 Category: Allergy & Immunology Authors: Imogen Moran, Danielle T. Avery, Kathryn Payne, Helen Lenthall, E.Graham Davies, Siobhan Burns, Winnie Ip, Mat ÿfffedas M. Oleastro, Ismail Reisli, Sukru Guner, Sevgi Keles, Luigi Notarangelo, Elissa K. Deenick, Christopher C. Goodnow, David Zahra, Rober Source Type: research