The effects of tracheal occlusion on Wnt signaling in a rabbit model of congenital diaphragmatic hernia

Tracheal occlusion (TO) reverses pulmonary hypoplasia (PH) in congenital diaphragmatic hernia (CDH), but its mechanism of action remains poorly understood. Wnt signaling plays a critical role in lung development, but few studies exist. The purpose of our study was to a) confirm that our CDH rabbit model produced PH which was reversed by TO and b) determine the effects of CDH +/ − TO on Wnt signaling.

Source: Journal of Pediatric Surgery - February 18, 2019 Category: Surgery Authors: Martina Mudri, Shane A. Smith, Christina Vanderboor, Jacob Davidson, Timothy R.H. Regnault, Andreana B ütter Source Type: research