Regulation of BK Channels by Beta and Gamma Subunits.

Regulation of BK Channels by Beta and Gamma Subunits.
Annu Rev Physiol. 2019 Feb 10;81:113-137
Authors: Gonzalez-Perez V, Lingle CJ
Abstract
Ca2+- and voltage-gated K+ channels of large conductance (BK channels) are expressed in a diverse variety of both excitable and inexcitable cells, with functional properties presumably uniquely calibrated for the cells in which they are found. Although some diversity in BK channel function, localization, and regulation apparently arises from cell-specific alternative splice variants of the single pore-forming α subunit ( KCa1.1, Kcnma1, Slo1) gene, two families of regulatory subunits, β and γ, define BK channels that span a diverse range of functional properties. We are just beginning to unravel the cell-specific, physiological roles served by BK channels of different subunit composition.
PMID: 30742788 [PubMed - in process]

Source: Annual Review of Physiology - February 10, 2019 Category: Physiology Authors: Gonzalez-Perez V, Lingle CJ Tags: Annu Rev Physiol Source Type: research