PERAMPANEL: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome

We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER.All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other antiepileptic drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next hours. All the cases showed a stroke-like lesion in MRI.PER may be an effective option in SE associated with MELAS syndrome.
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research