Ask DMine: Seizures and Brain Damage

Our weekly DiabetesMine advice column addresses seizures possibly caused by low blood sugar, and mitigating the resulting damage.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs

Related Links:

Publication date: Available online 21 September 2020Source: The Lancet Diabetes &EndocrinologyAuthor(s): Srikanth Bellary, Abd A Tahrani, Anthony H Barnett
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 21 September 2020Source: The Lancet Diabetes &EndocrinologyAuthor(s): Johannes F E Mann, Thomas Hansen, Thomas Idorn, Lawrence A Leiter, Steven P Marso, Peter Rossing, Jochen Seufert, Sayeh Tadayon, Tina Vilsbøll
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
In clinical trials of treatments for chronic pain, the percentage of participants who withdraw early can be as high as 50%. Major reasons for early withdrawal in these studies include perceived lack of efficacy and adverse events. Commonly used strategies for accommodating missing data include last observation carried forward, baseline observation carried forward, and more principled methods such as mixed-model repeated-measures and multiple imputation. All these methods require strong and untestable assumptions concerning the conditional distribution of outcomes after dropout, given the observed data. We review recent dev...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
This study examined whether NR also blunts the loss of intraepidermal nerve fibers induced by paclitaxel, which is associated with peripheral neuropathy. The work was conducted in female rats with N-methyl-nitrosourea (MNU)-induced tumors of the mammary gland to increase its translational relevance, and to assess the interaction of NR with paclitaxel and NR's effect on tumor growth. Once daily oral administration of 200 mg/kg NR p.o. beginning with the first of 3 i.v. injections of 6.6 mg/kg paclitaxel to tumor-bearing rats significantly decreased paclitaxel-induced hypersensitivity to tactile and cool stimuli, as well as ...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Publication date: 15 November 2020Source: Life Sciences, Volume 261Author(s): Kehinde Sulaimon Ayinde, Olamide Tosin Olaoba, Boyenle Ibrahim, Du Lei, Qian Lu, Xiaoxing Yin, Temitope Isaac Adelusi
Source: Life Sciences - Category: Biology Source Type: research
Authors: Tamaki S, Imaishi H Abstract Human cytochrome P450 (or CYP) inhibition rates were investigated in sera from high fat diet (HFD)-induced type 2 diabetes (T2D), T2D recovered, and asymptomatic mice models to verify whether P450 inhibition assays could be used for the detection of disease, evaluation of therapeutic effect, and early diagnosis of T2D. In T2D mice, the blood glucose levels markedly increased; while blood glucose levels of recovered mice exceeded 200 mg dL-1, these eventually returned to the levels seen in control mice. In asymptomatic mice fed with short term HFD (stHFD), no changes i...
Source: Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research
AbstractThe development of new diabetes treatment strategies has garnered much interest given that conventional management therapies for type 1 diabetes fail to provide optimal glycemic control while creating a high burden of self-care to patients. Stimuli-responsive, “closed-loop” systems are particularly attractive due to their ability to mimic dynamic ß cell function by releasing insulin in response to fluctuating glucose levels in real-time and with minimal patient discomfort. In this short review, we focus on stimuli-responsive, reservoir-based insulin delivery devices. We explore and evaluate system...
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 21 September 2020Source: European Journal of RadiologyAuthor(s): Ana I. Garcia Diez, David Fuster, Laura Morata, Ferran Torres, Ruben Garcia, Daniel Poggio, Santiago Sotes, Montserrat Del Amo, Jaime Isern-Kebschull, Jaume Pomes, Alex Soriano, Laura Brugnara, Xavier Tomas
Source: European Journal of Radiology - Category: Radiology Source Type: research
This week, I did something unplanned: I bought 2 vials of Lilly's " authorized generic " of its brand-name U-100 insulin analog branded as Humalog (insulin lispro rDNA origin) at my neighborhood Walgreens. The reason it was unplanned is because I already met the deductible for my insurance plan, so I hadn't expected to deal with this until it resets in January. But I had a script I last filled before I met the deductible, and the pharmacy sent a text telling me it was time to refill. In reality, I have insulin but its a different brand and a different pharmacy. But Walgreens wants a sale so it was telling me it i...
Source: Scott's Web Log - Category: Endocrinology Tags: Admelog Drug Channels drug prices GoodRx Humalog insulin Lilly prescriptions rebates Sanofi Source Type: blogs
More News: Brain | Diabetes | Endocrinology | Neurology | Sugar