A Contraindication for Transplantation? Consequences of Frailty on Immunity and Immunosuppression

AbstractPurpose of ReviewFrailty has gained clinical relevance. While the condition may negatively impact outcomes, organ transplantation may also improve frailty. Notably, available assessment tools are broad and have not allowed for a detailed analysis or prognosis.Recent FindingsFrailty has been linked to adverse surgical outcomes while imparting on immune competency. Immunosuppressive treatment may therefore require modifications in frail patients, and effects on drug metabolism may need consideration. Moreover, cognitive impairment may impact compliance. Here, we provide a comprehensive update on clinical features, diagnostics, consequences on immunity and immunosuppression, and clinical outcomes.SummaryClinical studies have shown promising outcomes for some frail transplant recipients. Relevant open questions include patient selection, adaptation of immunosuppression, potential to improve frailty, compliance, and transplant outcomes.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
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Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news
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Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Conclusions: This case suggests that even when the latest RBC antibody screen is negative after immunosuppression, clinicians should consider the possibility of the prior positive result. Emphasizing those results by the system would be supportive for safer patient management. PMID: 31304695 [PubMed - as supplied by publisher]
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research
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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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Source: Nursing Blogs at Johns Hopkins University - Category: Nursing Authors: Tags: Cardiovascular and Chronic Conditions New CVD Diabetes heart heart disease home care Hypertension LVAD obesity research transplant ventricular assist device Source Type: blogs
Authors: Golchin A, Shams F, Kangari P, Azari A, Hosseinzadeh S Abstract Cellular-based therapies have drawn a great deal of attention thanks to their regenerative medicine approaches to treat incurable diseases and specific injuries. In this regard, injectable cell delivery systems could actualize the therapeutically beneficial outcomes of cell-based therapeutic products. These systems have found considerable clinical uses. Hence, the recent studies have focused on developing injectable bio-constructs to protect transplanted cells during delivery and stimulating endogenous regeneration through interactions of thes...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Lymphoma, Large B-Cell, Diffuse Intervention:   Drug: gemcitabine, vinorelbine and doxorubicin liposome, with or without rituximab Sponsor:   Sun Yat-sen University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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