Thalidomide: Still an important second-line treatment in refractory cutaneous lupus erythematosus?

Journal of Dermatological Treatment, Ahead of Print.
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: article Source Type: research

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In this report, we present a patient with Raynaud’s phenomenon refractory to standard therapies whose symptoms resolved after treatment with BTX-A. Follow-up with the patient after one and five years showed no relapse or recurrence of symptoms. J Drugs Dermatol. 2019;18(9):943-945. PMID: 31524993 [PubMed - in process]
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Publication date: Available online 16 September 2019Source: Mammalian BiologyAuthor(s): Ana M. Figueiredo, Tânia Barros, Ana M. Valente, Carlos Fonseca, Luís Madeira de Carvalho, Rita Tinoco TorresAbstractAs a top predator, the Iberian wolf (Canis lupus signatus) plays a major role shaping interactions within food webs. Due to its conservation status in Portugal, i.e. endangered, it is important to understand the role of parasites in this population, since they can be a limiting factor for the population fitness and trophic interactions and, ultimately, their survival. From November 2017 to August 2018, 33 fre...
Source: Mammalian Biology - Category: Biology Source Type: research
When patients with lupus are hospitalized, they should be screened and likely treated for venous thromboembolism, researchers of a nationwide study say. In May, ACR Open Rheumatology published results of the large retrospective study spanning several years. Researchers analyzed trends in mortality, morbidity and hospitalization from venous thrombo­embolism (VTE), specifically among patients diagnosed with systemic... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Research Reviews SLE (Lupus) mortality risk venous thromboembolism Source Type: research
Sjögren's syndrome in Systemic Lupus Erythematosus - a subset characterized by a systemic inflammatory state. J Rheumatol. 2019 Sep 15;: Authors: Ruacho G, Kvarnström M, Zickert A, Oke V, Rönnelid J, Eketjäll S, Elvin K, Gunnarsson I, Svenungsson E Abstract OBJECTIVE: Secondary Sjögren's syndrome (SLE-sSS) is an often-neglected subset of patients with Systemic lupus erythematosus (SLE). Furthermore, primary Sjögren's syndrome overlaps and can be difficult to delineate from SLE. To shed light on the SLE-sSS subset, we investigated a large and well-characterized SLE cohort c...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Source: Critical Reviews in Food Science and Nutrition - Category: Nutrition Authors: Source Type: research
Causes of numbness in the thigh include lupus, some autoimmune conditions, and multiple sclerosis. Treatment depends on the cause. Learn more here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news
AbstractObjectivesCXC ligand 13 (CXCL13) is known as B cell chemotactic factor (BLC), promoting the migration of B lymphocytes by communicating with its receptor CXCR5, which can be regarded as part of pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This meta-analysis was to evaluate the circulating CXCL13 levels in SLE and RA.MethodsAll articles were respectively gathered from PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) (by the end of 10 April 2019). According to random effects model, standardized mean difference (SMD) and 95% confidence interval (CI) of CXC...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
TARGETING TARGETED TREATMENT FOR IMMUNE AND NON-IMMUNE KIDNEY DISEASES. Trans Am Clin Climatol Assoc. 2019;130:88-99 Authors: Tsokos GC, Tsokos MG Abstract We have found that calcium calmodulin kinase IV is increased in T cells, podocytes, and mesangial cells from patients with systemic lupus erythematosus, as well as in lupus-prone mice, podocytes of patients with focal segmental glomerulosclerosis, and in mice injected with doxorubicin. We showed that this accounts for aberrant T cell function and glomerular damage. Using nanoparticles (nlg) loaded with a small drug inhibitor of calcium calmodulin ki...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
ConclusionNLR and PLR appear to be potentially useful cheap parameters of activity, relapse and severity in SLE patients with nephritis.
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Conclusion: In conclusion, VDR rs2228570 and rs731236 polymorphisms and tAf haplotype were associated with SLE risk. PMID: 31516886 [PubMed]
Source: Biomed Res - Category: Research Authors: Tags: Adv Biomed Res Source Type: research
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