Flu-Like Illness Tied to Increased Relative Mortality in ESRD

THURSDAY, Jan. 24, 2019 -- Community activity for influenza-like illness (ILI) is associated with seasonal variation in all-cause mortality among patients with end-stage renal disease (ESRD), according to a study published online Jan. 24 in the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Publication date: Available online 23 March 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Lifen Han, Cong Chen, Xianlin Han, Shujin Lin, Xiulan Ao, Xiao Han, Jianmin Wang, Hanhui YeAbstractInfluenza A virus are a persistent and significant threat to human health, and current vaccines do not provide sufficient protection due to antigenic drift, which allows influenza viruses to easily escape immune surveillance and antiviral drug activity. Influenza hemagglutinin (HA) is a glycoprotein needed for the entry of enveloped influenza viruses into host cells and is a potential target for anti-influenza ...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Publication date: Available online 23 March 2019Source: Journal of Molecular BiologyAuthor(s): Md Shafiuddin, Adrianus C.M. BoonAbstractThe influenza A virus (IAV), a respiratory pathogen for humans, poses serious medical and economic challenges to global healthcare systems. The IAV genome, consisting of eight single-stranded viral RNA (vRNA) segments, is incorporated into virions by a complex process known as genome packaging. Specific RNA sequences within the vRNA segments serve as signals that are necessary for genome packaging. Even though efficient packaging is a prerequisite for viral infectivity, many of the mechani...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Adaptation of rabbits to myxoma virus (Science) Principal component analysis (YouTube) Image credit Letters read on TWiV 540 Timestamps by Jolene. Thanks! Weekly Science Picks...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
We describe a 45-year-old man with ARDS and progressive lung fibrosis secondary to H1N1 pneumonia who was treated for 45 days with venovenous extracorporeal membrane oxygenation as a rescue utility and bridge to bilateral lung transplantation. The patient was saved and lived well. Lung transplantation may be a viable alternative for patients with lung fibrosis secondary to H1N1-induced ARDS in very selected situations.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Salto-Quintana JN, Rivera-Alfaro G, Sánchez-Ramos EL, Gómez-Gómez A, Noyola DE Abstract Influenza is a leading cause of respiratory tract infections worldwide and there is limited information on the impact of the influenza A(H1N1)pdm virus on mortality after the 2009 pandemic. Using national mortality register data through 1998-2015 in Mexico, influenza-associated mortality was estimated for respiratory, cardiovascular, and all-cause events. The proportion of influenza-associated respiratory and cardiovascular deaths among different age groups were compared. There were 8,853,986 death ...
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
This study develops a non-parametric model based on Gaussian process regression for influenza prediction considering meteorological effect to capture temporal dependencies hidden in influenza time series. To identify the most explanatory external variables, L1-regularization is applied to identify meteorology factor subsets, and three types of covariance functions are designed to characterize non-stationary and periodic behavior in influenza activity. The dependencies of diseases and meteorology are modeled through the designed cross-covariance function. A real case in Shenzhen, China was studied to validate our proposed m...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
By MARC M. BEUTTLER, MD Every year at this time, you hear warnings that flu season has arrived. New data from the CDC indicates the season is far from over. So, you are urged by health authorities to get a flu shot. What you may not realize is how the flu can affect the hospitals you and your loved ones rely on for care.   In January, the large urban hospital where I am an intern faced the worst flu outbreak it has ever seen. Nearly 100 staff members tested positive for the flu. Residents assigned to back-up coverage were called to work daily to supplement the dwindling ranks of the sick. Every hospital vis...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Hospitals Medical Practice Marc Beuttler Vaccination Source Type: blogs
Cremin Honglin Chen Significantly higher numbers of human infections with H5N1 virus have occurred in Indonesia and Egypt, compared with other affected areas, and it is speculated that there are specific viral factors for human infection with avian H5N1 viruses in these locations. We previously showed PB2-K526R is present in 80% of Indonesian H5N1 human isolates, which lack the more common PB2-E627K substitution. Testing the hypothesis that this mutation may prime avian H5N1 virus for human infection, we showed that: (1) K526R is rarely found in avian influenza viruses but was identified in H5N1 viruses 2–3 yea...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Toll-like receptors (TLRs) coupled to intracellular signaling cascades function as central elements of innate immunity that control transcription of numerous pro-inflammatory genes. Two minor anionic phospholipids present in the pulmonary surfactant complex, palmitoyl-oleoyl-phosphatidylglycerol (POPG) and phosphatidylinositol (PI), antagonize the cognate ligand activation of TLRs 2 and 4. The lipids block recognition of activating ligands by the TLRs, either directly or via the TLR4 coreceptors CD14 and MD2. Antagonism of TLR activation results in inhibition of the initiating step of the pro-inflammatory signaling pathway...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: ASBMB Award Articles Source Type: research
In this study, we report the crystal structures of two additional human H5N1 antibodies isolated from H5N1-infected individuals, 3C11 and AVFluIgG01, bound to the head at 2.33- and 2.30-Å resolution, respectively. These two new antibody epitopes have large overlap with and extend beyond the original VS1. Site-directed mutagenesis experiments identified eight pivotal residues (Ser-126b, Lys-165, Arg-166, Ser-167, Tyr-168, Asn-169, Thr-171, and Asn-172) critical for 65C6-, 3C11-, and AVFluIgG01-binding and neutralization activities. These residues formed a unique “Y”-shaped surface on H5N1 globular head and...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Source Type: research
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