Metrics of Aging in Transplantation

AbstractPurpose of ReviewTo describe potential metrics of aging beyond chronological age and their associations with outcomes after solid organ transplantation.Recent FindingsInvestigation in this field has focused primarily on two areas: biomarkers related to replicative cell senescence and frailty and constructs related to frailty (e.g., sarcopenia, physical performance). Indicators of replicative senescence and frailty are more prevalent among transplant candidates than in the general elderly population, and both have been shown in recent studies to be associated with adverse outcomes following transplantation.SummaryDespite substantial evidence supporting the prognostic utility of these indicators, and of physical frailty in particular, no consensus has emerged about the best metric within individual organ specialty groups or across specialties. Research is ongoing to identify the most useful measure or set of measures.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Overexpression of TG2 enhances the differentiation of ectomesenchymal stem cells into neuron‑like cells and promotes functional recovery in adult rats following spinal cord injury. Mol Med Rep. 2019 Jul 15;: Authors: Shi W, Que Y, Lv D, Bi S, Xu Z, Wang D, Zhang Z Abstract Ectomesenchymal stem cells (EMSCs) represent a type of adult stem cells derived from the cranial neural crest. These cells are capable of self‑renewal and have the potential for multidirectional differentiation. Tissue transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase family of Ca2+‑depend...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Publication date: Available online 20 July 2019Source: Mechanisms of DevelopmentAuthor(s): Lauren N. Ragle, Robert D. Bruno, Corinne A. Boulanger, Gilbert H. SmithAbstractLong-label retention has been used by many to prove Cairns' immortal strand hypothesis and to identify potential stem cells. Here, we describe two strategies using 5-ethynl-2′-deoxyuridine (EdU) to identify and understand the distribution of long-label-retaining mammary epithelial cells during formation of the mouse mammary ductal system. First, EdU was given upon two consecutive days per week during weeks 4 through 10 and analyzed for label retenti...
Source: Mechanisms of Development - Category: Biology Source Type: research
Authors: Caselli E, D'Accolti M, Soffritti I, Lanzoni L, Bisi M, Volta A, Berloco F, Mazzacane S Abstract Antimicrobial resistance (AMR) is currently one of the main concerns for human health.Due to its rapid increase and global diffusion, several common microbial infections might become not curable in the future decades, making it impossible to apply other lifesaver therapies, such as transplant or chemotherapy.AMR is frequently observed in hospital pathogens, due to selective pressure exerted by antibiotic use, and consistently with this, in the recent years, many actions have been proposed to limit AMR spread, i...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
We report here a huge ADPKD case of kidney transplantation concomitant with simple nephrectomy through thoracoabdominal approach that allows surgeons to manipulate the renal vessels, the adrenal grand, the trigonal ligament, and the lower pole of the kidney under the wide operative field. Because of the direct recognition of the surgical anatomy, it might be safe and feasible for simple nephrectomy in huge ADPKD patients undergoing concomitant kidney transplantation despite of the wide skin incision required by this approach.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
ConclusionNo conclusion can be drawn on the contribution of somatostatin analogs and immunosuppressant in the occurrence of severe cholecystitis. Prophylactic cholecystectomy is not indicated in patients with this medication.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We describe a technique for osteochondral allograft transplantation to the patella for an isolated patellar chondral lesion (unipolar).
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Authors: Kobbe G, Schroeder T, Rautenberg C, Kaivers J, Gattermann N, Haas R, Germing U Abstract Introduction: Myelodysplastic Syndromes (MDS) are a heterogeneous group of myeloid neoplasms arising in a multipotent hematopoietic stem cell. In about 50% of cases, chromosomal aberrations are detected, which can serve as clonal markers as well as important prognostic factors. In recent years, many somatic mutations have been recognized to be involved in the initiation and clonal evolution of MDS. They provide prognostic information, not only regarding the natural course of disease but also regarding the outcome of all...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Bai H, Wen J, Gong JP, Wu H, Yuan FC, Cao D, Wu YK, Lai X, Wang MH Abstract Liver ischemia-reperfusion injury (IRI) represents a risk factor for early graft dysfunction and an obstacle to expanding donor pool in orthotopic liver transplantation (OLT). Kupffer cells (KCs) are the largest antigen-presenting cell (APC) group and the primary modulators of inflammation in liver tissues. The vital role of Notch1/Jagged1 pathway in mouse OLT model has been reported, however, its potential therapeutic mechanism is unknown. Here, we made use of short hairpin RNA-Jagged1 and AAV-Jagged1 to explore the effects of Not...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
In this study, we compared the effect of transplantation of isolated Sca-1+ cells and c-Kit+ cells with that of the crude CDCs (CrCDCs). Focusing on the differences in the ability for secretion of paracrine factors among 3 types of cells, we determined the effects of transplantation of these cells on cardiac intracellular signaling and mitochondrial function in rats with permanently ligated coronary arteries. We showed that the transplantation of these cells resulted in a preservation of the cardiac pump function and mitochondrial respiration at the 8th week after myocardial infarction. However, mitochondrial function in t...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Source: Gastroenterology - Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activity Source Type: research
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