Plasma Marker Predicts Allograft Failure in Lung Transplant

THURSDAY, Jan. 24, 2019 -- Donor-derived cell-free DNA (ddcfDNA) is a potential biomarker that can predict allograft failure after lung transplantation, according to a study published online Jan. 23 in EBioMedicine. Sean Agbor-Enoh, M.D., Ph.D.,...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news

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Conclusion: These findings suggest that Tubastatin A downregulates Th17 cell function and suppresses acute lung allograft rejection, at least partially, via the HIF-1α/ RORγt pathway.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
The continued shortage of donor organs, together with a sustained increase in the number of potential donors with hepatitis C virus (HCV) infection (related to the ongoing opioid epidemic) and the advent of direct acting antiviral agents(DAA), has led to increased utilization of HCV-positive donors for heart transplantation(HT) (1). Furthermore, multiple recent studies have shown that 1-year HT-survival using HCV-positive donors in the current era of DAAs is similar to HT-survival using non-HCV donors (1,2).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research correspondence Source Type: research
In this study, we investigated the efficacy of mitochondrial transplantation to enhance myocardial function of DCD hearts.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: yOriginal Pre-Clinical Science Source Type: research
This study aimed to verify the hypothesis that the application of dexmedetomidine during the perioperative period of liver transplantation can reduce the incidence of EAD and primary graft non-function (PNF). At the same time, the effects of dexm edetomidine application on perioperative renal function and lung function were studied.MethodsThis is a prospective, single-center, randomized, parallel-group study. Two hundred participants (18 –65 years) scheduled to undergo liver transplantation under general anesthesia will be included in this study. For participants in the treatment group, a loading dose of DEX w...
Source: Trials - Category: Research Source Type: clinical trials
Authors: Ghaidan H, Fakhro M, Lindstedt S Abstract Purpose: The influence of allograft ischemic time (IT) on short- and long-term mortality remains under debate in lung transplantation (LTx). Due to a scarcity in donors, better understanding of IT might improve the outcome after LTx. Methods: Between January 1990 and June 2016; 307 patients underwent LTx at Lund university hospital, Sweden. The end-point used was death/Re-LTx assessed by Cox regression and Kaplan-Meier survival. Results: Kaplan-Meier survival for mean IT (min) between subgroups ≤120, 121-240, 241-360 and 361+ showed significant difference for pa...
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Since the inception of lung transplantation, serial pulmonary function testing (PFT) has been key to quantifying allograft health. In 1993 an International Society for Heart and Lung Transplantation (ISHLT) consensus report standardized the approach to using PFT measures to benchmark lung allograft function1. Specifically chronic graft dysfunction, or bronchiolitis obliterans syndrome (BOS), was suggested by a sustained ≥20% decline in forced expiratory volume in 1 second (FEV1) as compared to the average of the two best posttransplant FEV1s measured at least three weeks apart in the absence of evident confounders1.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
: Circulating extracellular vesicles (EV) are raising considerable interest as a non-invasive diagnostic tool as they are easily detectable in biological fluids and contain specific set of nucleic acids, proteins, and lipids reflecting pathophysiological conditions. We aimed to investigate differences in plasma-derived EV surface-protein profile as biomarker to be used in combination with endomyocardial biopsies (EMB) for the diagnosis of allograft rejection.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
CONCLUSIONS: These findings demonstrate that telomere dysfunction isolated to airway epithelial cells leads to airway-centric lung remodeling and fibrosis similar to that observed in patients with CLAD and suggest that lung epithelial cell telomere dysfunction may be a molecular driver of CLAD. PMID: 32551854 [PubMed - as supplied by publisher]
Source: Am J Respir Cell Mol... - Category: Respiratory Medicine Authors: Tags: Am J Respir Cell Mol Biol Source Type: research
In this study, we identified PLK1 as a promoter of myofibroblast differentiation and investigated the mechanism by which its inhibition alleviates transplant-associated obliterative bronchiolitis (OB) during CAD. High-throughput bioinformatic analyses and experiments using the murine heterotopic tracheal transplantation model revealed that PLK1 is upregulated in grafts undergoing CAD as compared with controls, and that inhibiting PLK1 alleviates OB in vivo. Inhibition of PLK1 in vitro reduced expression of the specific myofibroblast differentiation marker α-smooth muscle actin (α-SMA) and decreased phosphorylat...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Conclusion: Increased acid exposure on pretransplant reflux testing was associated with the development of BOS and CLAD, both measures of chronic allograft rejection, after lung transplantation, and may provide clinically relevant information to improve lung allograft survival through aggressive reflux management.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
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