Dance Biopharm Finds Its Rhythm

Dance Biopharm had a lot to celebrate in 2018 and if all goes according to plan the private biotech company will have even more to celebrate this year. The company's flagship product – an insulin product delivered via a smart handheld soft mist inhaler – is currently in two confirmatory phase II studies in type 1 and 2 diabetes patients, and Dance plans to initiate two phase III programs in type 2 diabetes patients in 2019. "2018 was a year where Dance really started to build momentum and come out of stealth mode to move toward a commercially focused company," said Anne Whitaker, who joined Dance in September as director and CEO. Whitaker has worked with diabetes pharmaceutical products at all stages of the product lifecycle and is expected to lead the company's transformation from late-stage development to preparing its lead clinical asset, Dance 501, for commercialization.  In June 2018, the company completed a new private equity financing round securing $24.5 million. SternAegis Ventures, through Aegis Capital Corp., acted as the exclusive placement agent for the offering.  Molex Ventures, a subsidiary of Koch Industries also made a substantial equity investment in Dance and helped anchor the round. "This company is well positioned to transform diabetes care by taking the complexity out of insulin delivery and addressing the spe...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news

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ConclusionOur study indicates a direct link between systemic inflammation and the timely progression of type 1 DM. In patients with type 2 DM, no statistical significance was found between the levels of studied biomarkers and the occurrence of microvascular complications. Nephropathy appeared sooner in type 1 DM patients, while retinopathy and neuropathy had a similar pattern of occurrence in both types of patients.
Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
J Neurol Surg A Cent Eur Neurosurg DOI: 10.1055/s-0040-1701619 Study Aims Electromyographic (EMG) recordings of the fibularis longus and tibialis anterior muscles were performed intraoperatively during nerve decompression (ND) of the common fibular nerve (CFN) in patients with symptomatic diabetic sensorimotor peripheral neuropathy. Patient demographics and clinical attributes were compared against changes in EMG after ND and analyzed for possible correlations. Methods Intraoperative changes in CFN EMG were analyzed for correlations against sex, age, body mass index (BMI), hemoglobin A1c (A1c), and type and...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Original Article Source Type: research
Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported that reduced superoxide production is associated with mitochondrial dysfunction in the kidneys of mouse models of type 1 DKD. We also demonstrated that humans with DKD have significantly reduced levels of mitochondrion-derived metabolites in their urine. Here we examined renal superoxide production in a type 2 diabetes animal model, the db/db mouse, and the role of a mitochondrial protectant, MTP-131 (also called elamipretide, SS-31, or Bendavia) in restoring renal su...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Metabolism Source Type: research
Population cohort study (263,830&2,864,670 people with type 1&2 diabetes respectively) found crude mortality rates for COVID-19 in people with diabetes of 138.3 and 260.6 per 100,000 persons for type 1&2 respectively, with general population rate being 38.8/100,000.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Authors: Hernández M, Mauricio D Abstract Latent autoimmune diabetes in adults (LADA) is still a poorly characterized entity. However, its prevalence may be higher than that of classical type 1 diabetes. Patients with LADA are often misclassified as type 2 diabetes. The underlying autoimmune process against β-cell has important consequences for the prognosis, comorbidities, treatment choices and even patient-reported outcomes with this diabetes subtype. However, there is still an important gap of knowledge in many areas of clinical relevance. We are herein focusing on the state of knowledge of relevant ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
The risk of death from COVID-19 is three and a half times higher for patients with type 1 diabetes and two times higher for those with type 2 diabetes, compared with people without the condition, new NHS research shows.
Source: GP Online News - Category: Primary Care Tags: Coronavirus Source Type: news
Clinical practice guidelines on diabetes mellitus and pregnancy: Ι. Pre-existing type 1 and type 2 diabetes mellitus. Hormones (Athens). 2020 May 15;: Authors: Anastasiou E, Farmakidis G, Gerede A, Goulis DG, Koukkou E, Kourtis A, Mamopoulos A, Papadimitriou K, Papadopoulos V, Stefos T Abstract Women with type 1 (T1DM) or type 2 diabetes (T2DM) diagnosed prior to pregnancy are classified as having pre-existing diabetes mellitus (DM). The prevalence of hyperglycemia in pregnancy has been estimated at 17% globally and 5.4% in Europe, differences existing among racial and ethnic groups, following the...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
AbstractOne of the biochemical abnormalities found in diabetic tissues is a decrease in the cytosolic oxidized to reduced forms of nicotinamide adenine dinucleotide ratio (NAD+/NADH aka Pseudohypoxia) caused by oxidation of excessive substrates (glucose through polyol pathway, free fatty acids and lactate). Subsequently, a decline in NAD+ levels occurs due to the activation of poly adenine nucleotide diphosphate ‐ribose polymerase (mainly in type 1 diabetes) or the inhibition of adenine nucleotide monophosphate‐activated protein kinase (in type 2 diabetes). Thus, replenishment of NAD+ levels by nicotinamide ‐related ...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: REVIEW ARTICLE Source Type: research
AbstractThe aim of this narrative review is to update the current knowledge on the differential choice of circulating cardiac biomarkers in patients with prediabetes and established type 2 diabetes mellitus (T2DM). There are numerous circulating biomarkers with unconfirmed abilities to predict clinical outcomes in pre-DM and DM individuals; the prognostication ability of the cardiac biomarkers reported here has been established, and they are still being studied. The conventional cardiac biomarkers, such as natriuretic peptides (NPs), soluble suppressor tumorigenisity-2, high-sensitivity circulating cardiac troponins and ga...
Source: Diabetes Therapy - Category: Endocrinology Source Type: research
To investigate the prognostic value of estimated glomerular filtration rate (eGFR) and albuminuria in determining pregnancy outcomes in women with type 1 and type 2 diabetes.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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