The Efficacy of Systemic Doxycycline Adminstration as an Inhibitor of Intimal Hyperplasia After Balloon Angioplasty Arterial Injury

Intimal hyperplasia (IH) is the most common indicator for secondary intervention in peripheral vascular disease. Matrix metalloproteinases (MMPs) play a role in IH development due to their degradation of the extracellular matrix. Doxycycline, a member of the tetracycline family of antibiotics, is a potent MMP inhibitor. We have previously shown doxycycline inhibits MMP activity and VSMC migration in vitro. We hypothesized that doxycycline would decrease MMP activity in vivo and inhibit the development of IH in a rodent model of vascular injury.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Clinical Research, Basic Science Source Type: research