Breast MRI helps guide DCIS treatment

Breast MRI -- along with tests that characterize breast cancer genes -- can...Read more on AuntMinnie.comRelated Reading: Breast MRI works for evaluating equivocal DBT findings High-risk women benefit from twice-yearly breast MRI Breast MRI underutilized in high-risk women Breast MRI improves PPV for BI-RADS category 4B lesions Multiparametric MRI shines for suspected breast cancer
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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AbstractPurposeThe future of non-operative management of DCIS relies on distinguishing lesions requiring treatment from those needing only active surveillance. More accurate preoperative staging and grading of DCIS would be helpful. We identified determinants of upstaging preoperative breast biopsies showing ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC), or of upgrading them to higher-grade DCIS, following examination of the surgically excised specimen.MethodsWe studied all women with DCIS at preoperative biopsy in a large specialist cancer centre during 2000 –2014. Information from clinical records...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
AbstractPurposeIt has been accepted that radiation therapy (RT) for ductal carcinoma in situ (DCIS) has no survival benefit despite increasing local control. However, a recent large database study reported a small but significant benefit. Using a Korean population-based large database, we examined the survival benefit of RT for DCIS after breast-conserving surgery (BCS) and analyzed which subgroup might derive benefit from it.MethodsData from 6038 female DCIS patients who underwent BCS with or without RT between 1993 and 2012 were included in this study. We used propensity score analysis to control for differences in basel...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
We examined the hazard function adjusted for adherence to surveillance mammography to examine variations in LR risk and the effect of RT over time.MethodsCrude hazard estimates for the development of LR in a population cohort of DCIS treated by BCS  ± RT were computed. Multivariable extended Cox models and hazard plots were used to examine the association between receipt of RT and risk of each outcome adjusted for baseline covariates and adherence to mammography.ResultsPopulation cohort includes 3262 women treated by BCS; 1635 received RT. Median follow-up was 13  years. LR developed in 364 women ...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionsThe presence of multiple foci of MI in DCIS is associated with higher 15-year risks of invasive LR after breast-conserving therapy compared to women with pure DCIS but treatment with whole breast and boost RT can mitigate this risk.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionFurther functional studies to decipher the role of IDH2 and its mechanism of action as a driver of BC progression and LVI are warranted.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionsIn our retrospective study, re-excision for positive margin after initial BCS in invasive breast cancer does not contribute to prevent IBTR and may not translate into improved OS. Further treatment should be considered when patient was younger and margin status was invasive component.Legal entity responsible for the studyKenjiro Jimbo.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThe results of our study could be useful for enhance the role of MTD and identify unmet needs in decision making process in EBC.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsER- DCIS has an aggressive phenotype and a distinct biology. It is more likely to present as loco-regional or metastatic disease. Identification of genomic biomarkers, PD-L1 analysis in the tumor and the TILs is currently being undertaken. The molecular drivers and immunologic markers of recurrence in ER negative DCIS continue to be an active area of exploration. Further characterization of ER- DCIS immune microenvironment may identify useful targets for immune-based therapy and breast cancer prevention.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors ha...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: DBT significantly improved early-detection measures but did not significantly reduce ICR (relative to DM screening), suggesting that it could add benefit as well as adding over-detection in population BC screening. PMID: 31607526 [PubMed - as supplied by publisher]
Source: Breast - Category: Cancer & Oncology Authors: Tags: Breast Source Type: research
ConclusionsLong-term breast reconstruction complication rates are higher than previously anticipated, with increased rates of complications noted in the IBBR group. Patients should be counseled that IBBR is associated with higher rates of complications, including unplanned return to the OR, compared to ATR.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | DCIS (Ductal Carcinoma in Situ) | Ductal Carcinoma | Genetics | Women