Anticancer drug candidate inhibits lethal aggregation of mutant tumor suppressor protein

(Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB)) Brazilian researchers are the first to demonstrate the action of the synthetic compound PRIMA-1 (p53 reactivation with induction of massive apoptosis-1) against amyloid aggregates of mutant p53 protein, structure found in more than half of malignant tumors.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news