Risk-targeted incentives may bolster CT lung screening
CT lung cancer screening programs that offer incentives for screening individuals...Read more on AuntMinnie.comRelated Reading: New decision aids may revamp CT lung cancer screening Are patients adequately informed about CT lung screening? 3 steps to personalized CT lung cancer screening Risk-based CT lung screening could be more efficient Risk-based lung cancer screening tops USPSTF guidelines
This study evaluated the accuracy of NAVIFY Mutation Profiler, a cloud-based CE-IVD software that aids in interpreting clinically relevant variants detected in somatic oncology next-generation sequencing (NGS) tests. This tool reports tiered classifications based on different levels of clinical evidence from a highly curated, regularly updated database derived from medical guidelines, drug approvals, and peer reviewed literature. A retrospective analysis was performed on NGS results from 37 lung cancer cases treated with chemotherapy (n=10), EGFR tyrosine kinase inhibitor (TKI) (n=5), or ALK TKI (n=22).
A peer review process that's driven by artificial intelligence (AI) can identify...Read more on AuntMinnie.comRelated Reading: C-MIMI: Use of AI in radiology is evolving Medical imaging AI market projected for strong growth Can AI diagnose heart failure on chest x-rays? AI aids classification of indeterminate lung nodules Ferrum deploys AI platform for lung cancer detection
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3. Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Referring providers are ordering CT lung cancer screening exams for individuals...Read more on AuntMinnie.comRelated Reading: Which smokers seek out CT lung cancer screening? Can radiomics improve CT lung cancer screening? AI aids classification of indeterminate lung nodules Education affects follow-up for CT lung screening exams AI converts low-dose CT scans to high-quality studies
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
There are a few key factors that predict which individuals who have smoked...Read more on AuntMinnie.comRelated Reading: Can radiomics improve CT lung cancer screening? AI aids classification of indeterminate lung nodules Education affects follow-up for CT lung screening exams Google AI accurately assesses CT lung screening scans Is shared decision-making CT lung screening's Trojan horse?
Abstract BACKGROUND: Decisions about lung cancer screening are inherently complex and create a need for methods to convey the risks and benefits of screening to patients. RESEARCH QUESTION: What kind of decision aids or tools are available to support shared-decision making for lung cancer screening? What is the current evidence for the effectiveness, acceptability and feasibility of those tools? STUDY DESIGN: and Methods: We conducted a systematic review of studies and searched PubMed, MEDLINE, EMBASE, Cochrane Clinical Trials Register and ClinicalTrials.gov from inception to December 2019 for studies th...
CONCLUSIONS: Lung cancer screening represents an evidence-based approach for reducing lung cancer morbidity and mortality among chronic high frequency smokers. Culturally targeting evidence-based lung cancer screening decision-aids to the language, cultural and health literacy needs of high risk populations may increase uptake of lung cancer early detection screening. PMID: 32605737 [PubMed - as supplied by publisher]
CONCLUSION: DNA methylation-based biomarkers in plasma and urine could be useful as an adjunct to CT screening to guide decision-making regarding further invasive procedures in patients with pulmonary nodules. PMID: 32430478 [PubMed - as supplied by publisher]