Butenolides, triterpenoids and phenylethanoid glycosides from Plantago depressa

Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Xiu-Qing Song, Jie Bao, Jia Sun, Zhi-Qiang Cheng, Yuying Zhang, Jin-Hai Yu, Cheng-Shi Jiang, Hua ZhangAbstractFour new compounds, including two butenolides (1 and 2), an arborinane-type triterpenoid (3) and a phenylethanoid glycoside (4), along with the known triterpenoids (5–17) and phenylethanoid glycosides (18–29), were isolated from whole plants of Plantago depressa. The structures of the isolated compounds were elucidated by comprehensive spectroscopic analyses and were evaluated for their anti-inflammatory or antiradical activities. Our results underlined that, among compounds 1–17, only compound 16 inhibited lipopolysaccharide-induced NO production with an IC50 equal to 5.33 ± 0.51 μM. All phenylethanoid glycosides (4, 18–29) were evaluated for their antiradical activity with a DPPH radical scavenging bioassay and showed high to moderate effect (IC50 from 2.70 to 51.51 μM).Graphical abstractTwenty-nine compounds including four new ones of two butenolides, a triterpenoid and a phenylethanoid glycoside, were isolated from Plantago depressa. Selective compounds showed anti-inflammatory and antiradical activities.

Source: Phytochemistry Letters - January 11, 2019 Category: Chemistry Source Type: research