Treatment of established TH2 cells with 4 μ8c, an inhibitor of IRE1α, blocks IL-5 but not IL-4 secretion

T cell activation induces ER stress and upregulates Inositol Requiring Enzyme 1 alpha (IRE1 α), an activator of the unfolded protein response (UPR) pathway. Inhibition of IRE1α RNase activity in activated CD4+ spl...

Source: BMC Immunology - January 10, 2019 Category: Allergy & Immunology Authors: Cody Poe, Cheyanne Youngblood, Karissa Hodge and Kyeorda Kemp Tags: Research article Source Type: research