Barrier to resistance of dolutegravir in two-drug combinations.

Barrier to resistance of dolutegravir in two-drug combinations.
Antimicrob Agents Chemother. 2019 Jan 02;:
Authors: Yoshinaga T, Miki S, Kawauchi-Miki S, Seki T, Fujiwara T
Abstract
A major concern when using two-drug anti-HIV regimens is the risk of viral resistance. However, no techniques to evaluate the barrier to resistance of two-drug combinations in vitro have been reported. We evaluated the emergence of drug-resistant mutants in a passage study with constant concentrations of two drugs simultaneously. The barrier to resistance of dolutegravir-containing two-drug combinations was higher than the other combinations evaluated in this study.
PMID: 30602514 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - January 2, 2019 Category: Microbiology Authors: Yoshinaga T, Miki S, Kawauchi-Miki S, Seki T, Fujiwara T Tags: Antimicrob Agents Chemother Source Type: research