Freezing Induced Turn-on Modality for Real-time Imaging in Cryosurgery.

Freezing Induced Turn-on Modality for Real-time Imaging in Cryosurgery. Angew Chem Int Ed Engl. 2019 Jan 02;: Authors: He Z, Liu P, Zhang S, Yan J, Wang M, Cai Z, Wang J, Dong Y Abstract Cryosurgery has attracted great attention for the treatment of tumors due to its obvious advantages. However, it still remains a challenge to determine the volume of frozen tissues in real-time, which greatly lowers the therapeutic efficacy of cryosurgery and hinders its broad application for the treatment of cancers. Herein, we report a freezing induced turn-on strategy for selective real-time imaging of frozen cancer cells. As a type of aggregation induced emission (AIE) fluorogen, TABD-Py molecules interact specifically with ice crystals and form aggregates at the ice/water interface. Consequently, bright fluorescent emission appears upon freezing. Note that TABD-Py molecules are enriched only in the cancer cells and exhibit high biocompatibility as well as low cytotoxicity, therefore a freezing induced turn-on imaging modality for cryosurgery is developed, which will certainly maximize therapeutic efficacy of cryosurgery in treating tumors. PMID: 30600879 [PubMed - as supplied by publisher]
Source: Angewandte Chemie - Category: Chemistry Authors: Tags: Angew Chem Int Ed Engl Source Type: research