The route of administration dictates the immunogenicity of peptide-based cancer vaccines in mice

We report here that peptide vaccines and poly-ICLC adjuvant administered via the unconventional intravenous route of immunization generate substantially higher CTL responses as compared to conventional subcutaneous injections, resulting in more successful antitumor effects in mice. Fu rthermore, amphiphilic antigen constructs such as palmitoylated peptides were shown to be better immunogens than long peptide constructs, which now are in vogue in the clinic. The present findings if translated into the clinical setting could help dissipate the wide-spread skepticism of whether pept ide vaccines will ever work to treat cancer.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research