Clinical Validation of a Protein Biomarker Panel for Non-Small Cell Lung Cancer.

Clinical Validation of a Protein Biomarker Panel for Non-Small Cell Lung Cancer. J Korean Med Sci. 2018 Dec 31;33(53):e342 Authors: Jung YJ, Oh IJ, Kim Y, Jung JH, Seok M, Lee W, Park CK, Lim JH, Kim YC, Kim WS, Choi CM Abstract We validated the diagnostic performance of a previously developed blood-based 7-protein biomarker panel, AptoDetect™-Lung (Aptamer Sciences Inc., Pohang, Korea) using modified aptamer-based proteomic technology for lung cancer detection. Non-small cell lung cancer (NSCLC), 200 patients and benign nodule controls, 200 participants were enrolled. In a high-risk population corresponding to ≥ 55 years of age and ≥ 30 pack-years, the diagnostic performance was improved, showing 73.3% sensitivity and 90.5% specificity with an area under the curve of 0.88. AptoDetect™-Lung (Aptamer Sciences Inc.) offers the best validated performance to discriminate NSCLC from benign nodule controls in a high-risk population and could play a complementary role in lung cancer screening. PMID: 30595683 [PubMed - in process]
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research