Pulmonary Consequences of Acute Kidney Injury

Summary: Mortality rates among critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy typically exceed 50%, rates that have not improved significantly despite ongoing advancements in renal replacement therapy. A growing body of animal and human data have accumulated over the past 2 decades that have shown that AKI is associated with a series of distant organ effects that may contribute to the persistently high mortality of AKI. In this review, we describe the pulmonary sequelae of AKI, focusing on mechanisms of pulmonary edema in the context of traditional complications of AKI (eg, volume overload, acidosis) and nontraditional complications of AKI (eg, systemic inflammation).

Source: Seminars in Nephrology - December 31, 2018 Category: Urology & Nephrology Authors: J. Pedro Teixeira, Sophia Ambruso, Benjamin R. Griffin, Sarah Faubel Source Type: research