Green synthesis of phosphoryl-2-oxo-2H-pyran via three component reaction of trialkyl phosphites.

Green synthesis of phosphoryl-2-oxo-2H-pyran via three component reaction of trialkyl phosphites.
Comb Chem High Throughput Screen. 2014 Nov 11;
Authors: Hossaini Z, Sheikholeslami-Farahani F, Rostami-Charati F
Abstract
An effective one-pot synthesis of dialkoxyphosphoryl-2-oxo-2H-pyran derivatives by three-component reaction of alky bromides and dialkyl acetylenedicarboxylates in the presence of trialkyl phosphite is described. The reactions were performed under solvent-free conditions at 50oC and neutral conditions and provided good yields of products.
PMID: 25386707 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - November 11, 2014 Category: Chemistry Authors: Hossaini Z, Sheikholeslami-Farahani F, Rostami-Charati F Tags: Comb Chem High Throughput Screen Source Type: research