Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells

The pathogen Salmonella enterica (Se) can paradoxically persist in hosts while being controlled by IFN- γ-producing Th1 cells. Goldberg et al. show that the bacteria survive by resisting the effects of toxic host molecules in myeloid cells within granulomas, in areas lacking T cells. Infection is constrained by Th1 cells positioned around the granuloma via the CXCR3-CXCL9/10 chemokine axis.

Source: Immunity - December 11, 2018 Category: Allergy & Immunology Authors: Michael F. Goldberg, Elizabeth K. Roeske, Lauren N. Ward, Thomas Pengo, Thamotharampillai Dileepan, Dmitri I. Kotov, Marc K. Jenkins Tags: Article Source Type: research